CAS: 34883-43-7; 2,4'-Dichloro-1,1'-Biphenyl

该化合物是一种氯化联苯化合物,其特点是在联苯结构的2和4位置上存在氯原子,该化学品主要用作有机合成和研究应用中的中间体,因为其稳定的芳香框架和交叉反应中的回动性,其定义明确的结构对研究多氯联苯行为,环境持久性和降解途径很有价值.该化合物的纯度和一致性对于环境和毒理学研究中的分析标准和参考材料至关重要.由于其潜在的毒性和环境影响,适当的处理和储存至关重要.

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上下游产品

2,4'-diaminobiphenyl 3-chloro-4-(4-chlorophenyl)benzenamine biphenyl p-chlorobenzenediazonium tetrafluoroborate biphenyl

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    专利信息


    专利号:US-7071207-B2
    优先权日:2001-09-24
    标题 :Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity
    发明人：SMITH ROGER A; O'CONNOR STEPHEN J; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C; FAN JIANMEI; ZHANG ZHONGHUA; LAVOIE RICO C; PODLOGAR BRENT L
    权利人:BAYER PHARMACEUTICALS CORP
    摘要:This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

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    主要参考文献

    [参考文献]: A J Lambo, Et Al. Temperature-Dependent Biotransformation Of 2,4'-Dichlorobiphenyl By Psychrotolerant Hydrogenophaga Strain Ia3-A: Higher Temperatures Prevent Excess Accumulation Of Problematic Meta-Cleavage Products. Lett Appl Microbiol. 2007 Apr;44(4):447-53.
    [参考文献]: J Olivero-Verbel, Et Al. Effect Of Three Polychlorinated Biphenyls On F-Met-Leu-Phe-Induced Degranulation In Rat Neutrophils. Toxicol Lett. 1998 Sep 15;98(3):195-202.
    [参考文献]: M W Kennedy, Et Al. Metabolism Of Dichlorobiphenyls By Hepatic Microsomal Cytochrome P-450. Biochem Pharmacol. 1981 Mar 15;30(6):577-88.
    [参考文献]: Qi Lin, Et Al. [参考文献]: Ying Yong Sheng Tai Xue Bao. 2005 Apr;16(4):688-92.
    [参考文献]: Robert M Burgess, Et Al. Sorption Of 2,4'-Dichlorobiphenyl And Fluoranthene To A Marine Sediment Amended With Different Types Of Black Carbon. Environ Toxicol Chem. 2004 Nov;23(11):2534-44.

    合成参考文献


    摘要:Kim, H.; Yoshida , J., Science of Synthesis: Flow Chemistry in Organic Synthesis, (2018) 1, 228.
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    摘要:Miyagishi, H. V.; Nagaki, A., Science of Synthesis: Knowledge Updates, (2024) 1, 226.
    参考文献:10.1007/s00284-005-0194-8
    摘要:Lambo AJ, Patel TR. Cometabolic degradation of polychlorinated biphenyls at low temperature by psychrotolerant bacterium Hydrogenophaga sp. IA3-A. Curr Microbiol. 2006 Jul;53(1):48–52. doi: 10.1007/s00284-005-0194-8.
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