专利号:US-RE37160-E 优先权日:1990-06-12 标题:Synthesis of tyrosine derived diphenol monomers 发明人:KOHN JOACHIM B; HOOPER KIMBERLY A 权利人:UNIV RUTGERS 摘要:A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-solvent urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a water-immiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also disclosed.
专利号:US-RE37795-E 优先权日:1990-06-12 标 题 :Synthesis of tyrosine-derived diphenol monomers 发明人:KOHN JOACHIM B; BROCCHINI STEPHEN; SCHWARTZ ARTHUR L 摘要:A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-soluble urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a water-immiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also discussed.
专利号:US-10442757-B2 优先权日:2017-06-07 标 题 :Synthesis of tyrosine derived diphenol monomers 发明人:PULAPURA SATISH; BUEVICH FATIMA; CHEN XIANGJI; LYU SUPING 权利人:TYRX INC; MEDTRONIC INC 摘要:A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCI HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.
专利号:US-6380156-B1 优先权日:1996-10-24 标 题:Total synthesis of the amino hip analogue of didemnin A 发明人:RINEHART KENNETH L; KATAUSKAS ALEXANDRA J 权利人:UNIV ILLINOIS 摘要:Disclosed is a synthetic method for the preparation of analogs of Didemnin A (1), particularly the Amino-Hip analog of Didemnin A, also known as 'AipDidemnin A' (8). These compounds have the following structures:
专利号:US-4016147-A 优先权日:1975-01-16 标题:Method for preparation of low-phenylalanine plastein 发明人:FUJIMAKI MASAO; ARAI SOICHI; WATANABE MICHIKO 权利人:FUJI OIL CO LTD 摘要:Method for the preparation of a low-phenylalanine plastein comprising hydrolyzing stepwise a certain albumin or globulin protein with an endopeptidase having an affinity for the aromatic acid components, and an exopeptidase, subjecting the hydrolyzate thus-obtained to gel-filtration to divide it into two fractions, one being constituted with aromatic amino acids and the other being constituted with oligopeptides almost free from the aromatic amino acids, and then subjecting the latter fraction to usual plastein synthesis. Tyrosine and/or tryptophan may be added to the substrate at the plastein synthesis in order to incorporate them into the plastein molecules. The resultant plasteins may be purified through ultra-filtration in order to remove the remaining free amino acids and low-molecular peptides.
专利号:US-2006252134-A1 优先权日:1999-10-29 标 题 :Enantioselective oligomerization of alpha-hydroxy carboxylic acids and alpha-amino acids 发明人:LORBERT STEVE; SCHASTEEN CHARLES S; URAIZEE FAROOQ; KAPILA SHUBHENDER 权利人:NOVUS INT INC 摘要:An enzymatic synthesis and composition of oligomers and co-oligomers comprised of α-hydroxy carboxylic acids and α-amino acids or peptides is disclosed. In a preferred embodiment, a α-hydroxy carboxylic acid with a specific chiral configuration is linked by an amide linkage to a α-amino acid specific with a specific chiral configuration or linked by an amide linkage to a peptide made up of α-amino acid monomers having identical chiral configurations. Proteolytic enzymes catalyze oligomerization of the α-hydroxy carboxylic acid and α-amino acid. The degree and distribution of oligomerization varies upon the type and concentrations of different reaction mixtures utilized and upon the length of allowed reaction time. The resultant oligomers may be provided to animals such as ruminants as bioavailable amino acid supplements that are resistant to degradation in the rumen and other animals such as swine, poultry and aquatic animals.
参考文献:10.1023/b:bile.0000023025.35516.12 摘要:Kijima T, Izumi T. Fluorescence spectroscopic study of alpha-chymotrypsin relevant to the enantioselectivity for optical resolution of amino acid esters in organic solvents. Biotechnol Lett. 2004 Apr;26(8):655–8. doi: 10.1023/b:bile.0000023025.35516.12. 摘要:Yamane, M.; Narasaka, K., Science of Synthesis, (2004) 27, 611. 摘要:Aitken, R. A.; Aitken, K. M., Science of Synthesis, (2010) 41, 49.