CAS: 34081-17-9; Ethyl 2-Amino-3-(4-Hydroxyphenyl)Propanoate

该化合物是一种衍生物,其特点是存在乙酯组和盐酸盐形式.该化合物一般是白色的,白白的晶状粉,溶于水和酒精,与母氨酸相比,它增加了生物利用率.L-硫酸本身是一种非必要的氨酸,在...

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CAS号64-17-5 乙醇 | CAS号556-02-5 D-酪氨酸 | CAS号60-18-4 L-酪氨酸 | CAS号4985-46-0 L-酪氨酰胺 | CAS号142847-18-5 N-(叔丁氧羰基)-DL-酪氨酸 | CAS号949-67-7 L-酪氨酸乙酯 | CAS号60-18-4 L-酪氨酸 | CAS号556-02-5 D-酪氨酸 | CAS号64-17-5 乙醇 | CAS号73348-21-7 2-(3-bromo-4-hy...

合成工艺路线路线简述

    📜Dl-酪氨酸置于盐酸体系中,化学反应生成 L-酪氨酸乙酯盐酸盐
    参考文献:Losse Et Al.,Journal Fur Praktische Chemie (Leipzig 1954),1959,Vol. <4> 8,P. 339,342
    标题:Losse Et Al.,Journal Fur Praktische Chemie (Leipzig 1954),1959,Vol. <4> 8,P. 339,342

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    专利信息


    专利号:US-RE37160-E
    优先权日:1990-06-12
    标题:Synthesis of tyrosine derived diphenol monomers
    发明人:KOHN JOACHIM B; HOOPER KIMBERLY A
    权利人:UNIV RUTGERS
    摘要:A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-solvent urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a water-immiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also disclosed.

    专利号:US-RE37795-E
    优先权日:1990-06-12
    标 题 :Synthesis of tyrosine-derived diphenol monomers
    发明人:KOHN JOACHIM B; BROCCHINI STEPHEN; SCHWARTZ ARTHUR L
    摘要:A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-soluble urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a water-immiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also discussed.

    专利号:US-10442757-B2
    优先权日:2017-06-07
    标 题 :Synthesis of tyrosine derived diphenol monomers
    发明人:PULAPURA SATISH; BUEVICH FATIMA; CHEN XIANGJI; LYU SUPING
    权利人:TYRX INC; MEDTRONIC INC
    摘要:A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCI HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.

    专利号:US-6380156-B1
    优先权日:1996-10-24
    标 题:Total synthesis of the amino hip analogue of didemnin A
    发明人:RINEHART KENNETH L; KATAUSKAS ALEXANDRA J
    权利人:UNIV ILLINOIS
    摘要:Disclosed is a synthetic method for the preparation of analogs of Didemnin A (1), particularly the Amino-Hip analog of Didemnin A, also known as 'AipDidemnin A' (8). These compounds have the following structures:

    专利号:US-4016147-A
    优先权日:1975-01-16
    标题:Method for preparation of low-phenylalanine plastein
    发明人:FUJIMAKI MASAO; ARAI SOICHI; WATANABE MICHIKO
    权利人:FUJI OIL CO LTD
    摘要:Method for the preparation of a low-phenylalanine plastein comprising hydrolyzing stepwise a certain albumin or globulin protein with an endopeptidase having an affinity for the aromatic acid components, and an exopeptidase, subjecting the hydrolyzate thus-obtained to gel-filtration to divide it into two fractions, one being constituted with aromatic amino acids and the other being constituted with oligopeptides almost free from the aromatic amino acids, and then subjecting the latter fraction to usual plastein synthesis. Tyrosine and/or tryptophan may be added to the substrate at the plastein synthesis in order to incorporate them into the plastein molecules. The resultant plasteins may be purified through ultra-filtration in order to remove the remaining free amino acids and low-molecular peptides.

    专利号:US-2006252134-A1
    优先权日:1999-10-29
    标 题 :Enantioselective oligomerization of alpha-hydroxy carboxylic acids and alpha-amino acids
    发明人:LORBERT STEVE; SCHASTEEN CHARLES S; URAIZEE FAROOQ; KAPILA SHUBHENDER
    权利人:NOVUS INT INC
    摘要:An enzymatic synthesis and composition of oligomers and co-oligomers comprised of α-hydroxy carboxylic acids and α-amino acids or peptides is disclosed. In a preferred embodiment, a α-hydroxy carboxylic acid with a specific chiral configuration is linked by an amide linkage to a α-amino acid specific with a specific chiral configuration or linked by an amide linkage to a peptide made up of α-amino acid monomers having identical chiral configurations. Proteolytic enzymes catalyze oligomerization of the α-hydroxy carboxylic acid and α-amino acid. The degree and distribution of oligomerization varies upon the type and concentrations of different reaction mixtures utilized and upon the length of allowed reaction time. The resultant oligomers may be provided to animals such as ruminants as bioavailable amino acid supplements that are resistant to degradation in the rumen and other animals such as swine, poultry and aquatic animals.

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    合成参考文献


    参考文献:10.1023/b:bile.0000023025.35516.12
    摘要:Kijima T, Izumi T. Fluorescence spectroscopic study of alpha-chymotrypsin relevant to the enantioselectivity for optical resolution of amino acid esters in organic solvents. Biotechnol Lett. 2004 Apr;26(8):655–8. doi: 10.1023/b:bile.0000023025.35516.12.
    摘要:Yamane, M.; Narasaka, K., Science of Synthesis, (2004) 27, 611.
    摘要:Aitken, R. A.; Aitken, K. M., Science of Synthesis, (2010) 41, 49.
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