CAS: 33979-03-2; 2,2',4,4',6,6'-Hexachloro-1,1'-Biphenyl
该化合物是多氯联苯(PCB)同族体,其特点是六氯化物结构对称,该化合物由于在正方形,元形和分形位置存在氯原子,因而具有高度的热稳定性和化学惰性,这增强了其抗降解的抗力,主要被用作环境和毒理学研究的参考标准,用于分析多氯联苯污染并评估氯化有机污染物的持久性,其明确界定的结构和纯度使其对气体染色体-质谱学(GC-MS)应用中的校准很有价值,然而,其生物累积潜力和毒性需要在实验室环境中严格处理.
- 英文名称2,2',4,4',6,6'-Hexachloro-1,1'-Biphenyl
- 中文名称2,2',4,4',6,6'-六氯-1,1'-联苯
- IUPAC名称1,3,5-trichloro-2-(2,4,6-trichlorophenyl)benzene
- 其它别名2,2',4,4',6,6'-六氯二苯酚; 2,2',4,4',6,6'-Hexachlorobiphenyl
- CAS编号33979-03-2
- MFCD编号:MFCD00152541
- EINECS号:251-773-8
- FDA UNII编号:R9YK3084VS
- 分子式:C12H4Cl6分子量:360.88
- 产品CID: 1340498
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: ICOAEPDGFWLUTI-UHFFFAOYSA-N
- InChI=1S/C12H4Cl6/c13-5-1-7(15)11(8(16)2-5)12-9(17)3-6(14)4-10(12)18/h1-4H
- 计算化学: 氢键受体数*氢键供体数*可旋转键数1.0
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS08 & GHS09;
注释: Health hazard & Environment - 危险类别特定目标器官毒性-重复接触 类别2
水生急性毒性 类别1
水生慢性毒性 类别1 - 警示词Warning(警告)
- 危险描述H373 |长期或反复接触可能损害器官.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响. - 防范说明P260-P273-P391-P501
- 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
欧盟法规
《欧盟PIC法规》ECHA物质ECHA物质OtherC&L通报REACH预注册上下游产品
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- 合成目标产物 2,2',4,4',6,6'-Hexachlorobiphenyl 主要起始原料 3,5-Dichloronitrobenzene
- (文献来源)合成步骤主要原料 3,5-Dichloronitrobenzene
📜3,5-二氯硝基苯置于盐酸,Sodium Hydroxide,乙醇,硫酸,溶剂黄146,锌体系中,化学反应生成2,2',4,4',6,6'-六氯联苯
参考文献:Van Roosmalen,Recueil Des Travaux Chimiques Des Pays-Bas,1934,Vol. 53,P. 359,362
标题:Van Roosmalen,Recueil Des Travaux Chimiques Des Pays-Bas,1934,Vol. 53,P. 359,362
海关参考信息
- 2903919090-氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.1007/s00284-005-0194-8
摘要:Lambo AJ, Patel TR. Cometabolic degradation of polychlorinated biphenyls at low temperature by psychrotolerant bacterium Hydrogenophaga sp. IA3-A. Curr Microbiol. 2006 Jul;53(1):48–52. doi: 10.1007/s00284-005-0194-8.
参考文献:10.1016/j.taap.2006.04.013
摘要:Garner CE, Demeter J, Matthews HB. The effect of chlorine substitution on the disposition of polychlorinated biphenyls following dermal administration. Toxicol Appl Pharmacol. 2006 Oct 01;216(1):157–67. doi: 10.1016/j.taap.2006.04.013.
📝 需求与反馈
尽可能描述清楚需求与问题信息
