CAS: 20012-63-9; 2-(Benzyloxy)Aniline

上下游产品

2-benzyloxynitrobenzene benzyl bromide 2-(acetylamino)phenol 2-(2-(benzyloxy)phenyl) isoindoline-1,3-dione N-(2-(benzyloxy)phenyl)acetamide chloro-acetic acid-(2-benzyloxy-anilide) Benzyl-o-(p-toluolsulfonyl)aminophenylether N-(2-Benzyloxy-phenyl)-N'-(2-methoxy-phenyl)-oxalamide

硝苯酚置于铁粉,Potassium Carbonate,溶剂黄146体系中,用 丙酮 用作溶剂,40.0 °C,60.0 Kpa 条件下,反应 4.5H,反应生成2-苄氧基苯胺
参考文献:细胞毒性咔唑生物碱exavatine-A的首次全合成和对吡喃并[2,3-A]咔唑和[1,4]氧杂庚啶[2,3,4-Jk]咔唑的区域选择性环化
标题:细胞毒性咔唑生物碱exavatine-A的首次全合成和对吡喃并[2,3-A]咔唑和[1,4]氧杂庚啶[2,3,4-Jk]咔唑的区域选择性环化
摘要:我们描述了细胞毒性咔唑生物碱吉伐他汀-A的第一个全合成.咔唑骨架是通过使用我们的钯(II)催化的氧化环化作用,通过对二芳基胺的双ch键进行活化而构建的.用甲醛和其他添加剂处理中间体8-羟基咔唑可生成吡喃并[2,3-A ]咔唑或生成[1,4]恶唑并[2,3,4-Jk ]咔唑.研究了吡喃环化,以确定取代方式,添加剂和反应时间对选择性的影响.
Doi:10.1002/ejoc.201700515

专利信息

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-9284266-B2
优先权日:2012-01-19
标题:Method for synthesizing ramalin and ramalin precursor by using glutamic acid derivative and hydroxy aniline or hydroxy aniline having protected hydroxy group
发明人：YIM JOUNG HAN; KIM IL CHAN; KIM DOCKYU; HAN SE JONG; LEE HYOUNG SEOK; BHATTARAI HARI DATTA; KIM TAI KYOUNG; KIM KEUN SIK
权利人:YIM JOUNG HAN; KIM IL CHAN; KIM DOCKYU; HAN SE JONG; LEE HYOUNG SEOK; BHATTARAI HARI DATTA; KIM TAI KYOUNG; KIM KEUN SIK; KOREA INST OF OCEAN SCIENCE AND TECHNOLOGY
摘要:Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin.

专利号:US-6916949-B2
优先权日:2001-01-29
标 题 :Methods of chemical systhesis of phenolic nitrogen mustard prodrugs
发明人：SPRINGER CAROLINE JOY; NICULESCU-DUVAZ DAN
权利人:CANCER REC TECH LTD
摘要:This invention pertains to novel methods for the synthesis of certain nitrogen mustard prodrugs, such as N-{4-[N,N-bis(2-haloethylamino)-phenoxycarbonyl}-L-glutamic acid: wherein: X² is a halo group, and is -F, -Cl, -Br, or -I; n is an integer from 0 to 4; and, each R^A is an aryl substituent. The methods comprise, at least, the steps of: glutamate conjugation (GC); silyloxy deprotection (SD); and, sulfonic esterification (SU). Certain preferred methods comprise the steps of: amine substitution (AS); silyloxy protection (SP); phenolic deprotection (PD); activation (AC); glutamate conjugation (GC); silyloxy deprotection (SD); sulfonic estenfication (SU); halogenation (HL); glutamate deprotection (GD); and glutamic acid protection (GP).

专利号:WO-02060862-A1
优先权日:2001-01-29
标题:Methods of chemical synthesis of phenolic nitrogen mustard prodrugs

专利号:EP-1355876-B1
优先权日:2001-01-29
标题:Methods of chemical synthesis of phenolic nitrogen mustard prodrugs

专利号:EP-1355876-A1
优先权日:2001-01-29
标题 :Methods of chemical synthesis of phenolic nitrogen mustard prodrugs