CAS: 1747-60-0; 2-Amino-6-Methoxybenzothiazole

上下游产品

CAS号333-20-0 硫氰酸钾 | CAS号104-94-9 对甲氧基苯胺 | CAS号2293-07-4 对甲氧基苯基硫脲 | CAS号540-72-7 硫氰酸钠 | CAS号20265-97-8 对茴香胺盐酸盐 | CAS号1111-67-7 硫氰酸亚铜 | CAS号10205-69-3 6-methoxy-2-phe... | CAS号3427-30-3 2-氯-n-(6-甲氧基-苯并... | CAS号40925-65-3 6-甲氧基-2(3h)-苯并噻唑酮 | CAS号14372-79-3 Thi°Cyanic acid... | CAS号94-45-1 2-氨基-6-乙氧基苯并噻唑 | CAS号939-69-5 2-氰基-6-羟基苯并噻唑 | CAS号943-03-3 2-氰基-6-甲氧基苯并噻唑 | CAS号20174-70-3 2-肼基-6-甲氧基-1,3-苯并噻唑 | CAS号2605-14-3 2-氯-6-甲氧基苯并噻唑 | CAS号808755-67-1 2-溴苯并[d]噻唑-6-醇

对茴香胺盐酸盐置于溴体系中,用 氯仿,水 用作溶剂,化学反应 6.0H,反应生成2-氨基-6-甲氧基苯并噻唑
参考文献:Pharmacological Profile Of 6,12-Dihydro-3-Methoxy-1-Benzopyrano[3,4-B][1,4]Benzothiazin-6-One,A Novel Human Estrogen Receptor Agonist.
标题:Pharmacological Profile Of 6,12-Dihydro-3-Methoxy-1-Benzopyrano[3,4-B][1,4]Benzothiazin-6-One,A Novel Human Estrogen Receptor Agonist.
摘要:为了进一步确定 6,12-二氢-3-甲氧基-1-苯并吡喃并[3,4-B][1,4]苯并噻嗪-6-酮(1)的内分泌特征和与雌激素受体(er)的结合模式,我们进行了药理研究.化合物 1 的强效雌激素活性是通过测试其下调ers 和增强雌激素受体元件(ere)依赖性转录的能力来评估的.虽然化合物 1 未能与 [3H]E2 竞争与两种 Er 异构体的结合,但有证据表明它与 Mcf-7 细胞中的 Herα 发生了相互作用(er 下调/ere 依赖性荧光素酶诱导).因此,化合物 1 的活性开始需要激素结合结构域的适当构象,这很可能是由 Er 的协同调节因子赋予的.通过合成 9-甲氧基化衍生物 16 及其药理评估,我们提出了 1 与 Herα 的结合模式.化合物 1 似乎主要通过其 3-甲氧基取代基与激素结合域残基 His-524 的相互作用与 Erα 发生作用.
Doi:10.1248/bpb.25.335

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:BR-102015020840-B1
优先权日:2015-08-28
标题:BIPHENYL-DISULFIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PROCESS FOR SYNTHESIS OF BENZOTHIAZOLIC DERIVATIVES

专利号:US-6417195-B1
优先权日:1999-02-22
标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAL
权利人:LION BIOSCIENCE AG
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

专利号:US-5874443-A
优先权日:1995-10-19
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

专利号:US-4223031-A
优先权日:1978-05-05
标题 :Azolopyrimidinones
发明人：COVINGTON ROBERT R; TEMPLE JR DAVIS L; YEVICH JOSEPH P
权利人:MEAD JOHNSON & CO
摘要:6-(1H-Tetrazol-5-yl)thiozolo[3,2-a]pyrimidin-5-ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo-pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitory action on the immediate hypersensitivity reaction in mammals and relaxant action on the tracheal muscle. Intermediates in the synthesis of these substances from 2-aminoazoles and ethoxy-methylene malononitrile also have smooth muscle relaxant and immediate hypersensitivity reaction inhibitory activity.