专利号:US-10087221-B2 优先权日:2013-03-21 标题 :Synthesis of hydantoin containing peptide products 发明人:HENKEL BERND 权利人:SANOFI AVENTIS DEUTSCHLAND 摘要:The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.
专利号:US-6660832-B1 优先权日:1999-08-20 标题:Macrocyclic compounds and preparation methods thereof 发明人:JEFFERSON ELIZABETH; SWAYZE ERIC EDWARD 权利人:ISIS PHARMACEUTICALS INC 摘要:The present invention is directed to macrocyclic compounds of the formula (I)wherein Q, X, R1 and R5 are as defined herein. Compounds of the invention are useful for therapeutic and prophylactic treatment of bacterial infection in mammals. Solid phase synthetic procedures are provided effecting synthesis of the macrocyclic rings attached to a solid support.
专利号:EP-2976331-A1 优先权日:2013-03-21 标题:Synthesis of hydantoin containing peptide products
专利号:EP-2976331-B1 优先权日:2013-03-21 标题 :Synthesis of hydantoin containing peptide products
专利号:US-2016289282-A1 优先权日:2013-03-21 标 题 :Synthesis of Hydantoin Containing Peptide Products
专利号:CN-105189465-A 优先权日:2013-03-21 标题 :Synthesis of peptide products containing hydantoin
参考文献:10.1385/1-59259-798-x:169 摘要:Kim HS, Austin J, Hage DS. Screening major binding sites on human serum albumin by affinity capillary electrophoresis. Methods Mol Biol. 2004;276():169–87. doi: 10.1385/1-59259-798-x:169.