CAS: 16188-57-1; 2-Iodo-4-Methylphenol

相似化合物

60032-63-5 2296-23-3 1948-40-9

上下游产品

p-cresol 4,4'-dimethyl-2,2'-selanediyl-di-phenol sodium 4-methylphenoxide thallium p-cresolate 2-(2-hydroxy-5-methylphenylthio)benzoic acid 6-methylflavone (Z)-2-benzylidene-5-methylbenzofuran-3(2H)-one 2-iodo-4-methylphenyl-p-toluenesulfonate

📜对甲酚置于sodium Hypochlorite,Sodium Iodide,Sodium Hydroxide,盐酸,Sodium Thiosulfate体系中,用 甲醇,水 用作溶剂,以62%的收率获得2-碘-4-甲基苯酚
参考文献:铜(II)催化邻碘苯酚与芳基乙炔的多米诺合成2-芳基苯并[ B ]呋喃
标题:铜(II)催化邻碘苯酚与芳基乙炔的多米诺合成2-芳基苯并[ B ]呋喃
摘要:宽范围的2-芳基苯并[的b ]呋喃的合成通过分子间多米诺ç (芳基)-C ^ (炔基)键的形成,随后通过分子内ç (炔基)-ö经由铜(II)键形成的环化-催化的偶联ö-碘酚和芳基末端乙炔.该方法既不需要昂贵的钯催化剂,也不需要亲氧性膦配体,它们可以耐受不同的官能团.该方法成功地用于β-淀粉样聚集抑制剂5-氯-3-[4-(3-二乙基氨基丙氧基)苯甲酰基]-2-(4-甲氧基苯基)苯并呋喃的正式合成中.
Doi:10.1016/j.Tet.2010.01.026

专利信息

专利号:US-6495693-B2
优先权日:1996-11-22
标题:N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; FOLMER BEVERLY K; JOHN VARGHESE; LATIMER LEE H; NISSEN JEFFREY S; PORTER WARREN J; THORSETT EUGENE D; WU JING
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6486350-B1
优先权日:1998-09-30
标 题:Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
发明人：AUDIA JAMES E; HYSLOP PAUL A; NISSEN JEFFREY S; THOMPSON RICHARD C; TUNG JAY S; TANNER LAURA I
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are biological reagents which comprise compounds that inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism involved in the generation of beta-amyloid peptide.

专利号:US-7473786-B1
优先权日:2003-12-05
标题:Methods and systems for preparing fused heterocyclic compounds using copper(I) catalysts
发明人：VENKATARAMAN DHANDAPANI; BATES CRAIG G; SAEJUENG PRANORM
权利人:UNIV MASSACHUSETTS
摘要:A copper(I)-catalyzed procedure for the synthesis of benzo[b]heterocycles. This protocol can be used to synthesize a variety of 2-arylbenzo[b]furans and indoles in good to excellent yields. This method can tolerate a variety of functional groups, does not require the use of expensive additives and is palladium-free.

专利号:US-6096782-A
优先权日:1996-11-22
标 题:N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

专利号:WO-9822493-A2
优先权日:1996-11-22
标 题:N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

专利号:CN-1237978-A
优先权日:1996-11-22
标题 :N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising these derivatives and methods for inhibiting the release of beta-amyloid peptide and its synthesis using these compounds