CAS: 14639-25-9; 2-Pyridinecarboxylic Acid, Chromium Complex

2-氰基吡啶置于potassium Dichromate,硫酸,Sodium Carbonate体系中,用 甲醇,水 用作溶剂,以97.5%的收率获得吡啶甲酸铬
参考文献:一种直接还原法合成吡啶甲酸铬的方法
标题:一种直接还原法合成吡啶甲酸铬的方法
摘要:本发明涉及一种直接还原法合成吡啶甲酸铬的方法,包括以下步骤:(1)取10Kg~40Kg碱并溶于100L~450L水中,搅拌的同时进行加热,且加热至50oc~150oc;(2)缓慢滴入20Kg~80Kg的2‑氰基吡啶,待2‑氰基吡啶完全水解后,滴入酸来调节ph值至0.5~6.5;(3)将5Kg~50Kg铬盐投入到步骤(2)中制得的2‑吡啶甲酸溶液中,搅拌并升温到50oc~150oc;(4)再在上述步骤(3)制得的溶液中加入浓度为0.5%~50%还原剂水溶液直至溶液中无六价铬为止,并保温熟化0.5H~5H;(5)降温至50oc以下,并脱水过滤,将过滤物烘干即得到2‑吡啶甲酸铬.

专利信息

专利号:US-2007088086-A1
优先权日:1999-08-16
标题 :Method of using synthetic L-Se-methylselenocysteine as a nutriceutical and a method of its synthesis
发明人：SPALLHOLZ JULIAN E; REID TED W; WALKUP ROBERT D
权利人:PHARMASE INC
摘要:A synthesis of and use for L-Se-methylselenocysteine as a nutriceutical is described, based upon the knowledge that L-Se-methylselenocysteine is less toxic than L-selenomethionine towards normal cells. The synthesis proceeds by mixing N-(tert-butoxycarbonyl)-L-serine with a dialkyl diazodicarboxylate and at least one of a trialkylphosphine, triarylphosphine, and phosphite to form a first mixture that includes N-(tert-butoxycarbonyl)-L-serine β-lactone. Methyl selenol or its salt is mixed with the N-(tert-butoxycarbonyl)-L-serine β-lactone to form a second mixture that includes N-(tert-butoxycarbonyl)-Se-methylselenocysteine. The tert-butoxycarbonyl group is removed from the N-(tert-butoxycarbonyl)-Se-methylselenocysteine to form L-Se-methylselenocysteine. This synthesis significantly improves the manufacturability, manufacturing efficiency, and utility of this naturally occurring rare form of organic-selenium. L-Se-methylselenocysteine formed, for example, in this manner may be used as a nutriceutical for supplementation into the diets of humans or animals for various beneficial purposes, such as, for example, to prevent or reduce the risk of developing cancer.

专利号:EP-1205471-A1
优先权日:2000-10-02
标题:A method of using synthetic L-SE-Methylselenocysteine as a nutriceutical and a method of its synthesis
发明人：SPALLHOLZ JULIAN E; REID TED W; WALKUP ROBERT D
权利人:PHARMASE INC
摘要:A synthesis of and use of L-Se-methylselenocysteine as a nutriceutical isndescribed, based upon the knowledge that L-Se-methylselenocysteine is lessntoxic than L-selenomethionine towards normal cells. The synthesis proceedsnby mixing N-(tert-butoxycarbonyl)-L-serine with a dialkyl diazodicarboxylatenand at least one of a trialkylphosphine, triarylphosphine and phosphite to formna first mixture that includes N-(tert-butoxycarbonyl)-L-serine β-lactone.nMethyl selenol or its salt is mixed with the N-(tert-butoxycarbonyl)-L-serine β-lactonento form a second mixture that includes N-(tert-butoxycarbonyl)-Se-methylselenocysteine.nThe text butoxycarbonyl group is removed from the N-(tert-butoxycarbonyl)-Se-methylselenocysteinento form L-Se-methylselenocysteine.nThis synthesis significantly improves thenmanufacturability, manufacturing efficiency and utility of this naturallynoccurring rare form of organic-selenium. L-Se-methylselenocysteine formed,nfor example, in this manner may be used as a nutriceutical for supplementationninto the diets of humans or animals for various beneficial purposes, such as, fornexample, to prevent or reduce the risk of developing cancer.

专利号:WO-0007607-A1
优先权日:1998-08-04
标 题:Nutrient and therapeutic compositions for the treatment of cancer
权利人:KOSBAB JOHN V
摘要:This invention relates to nutrient and therapeutic compositions for the treatment of cancer symptoms and conditions. Compositions of this invention contain a mixture of antioxidants, components that promote collagen maintenance and synthesis, components that regulate blood lipids, glucose and/or insulin, and lower homocysteine levels. Compositions also provide supplementation for nutrient (vitamin, mineral and cofactor) deficiencies to restore and maintain normal biochemical function. Cancer formulations, particularly those adapted for treatment of female cancers, can be combined with components that provide benefit in osteoporosis.

专利号:US-11820834-B2
优先权日:2018-07-10
标题 :Polymorphic forms of Cyclo (-His-Pro) and methods of use to treat kidney disease
发明人：OLMSTEAD KAY; PEARSON DAVID; MCPHERSON ELAINE
权利人:NOVMETAPHARMA CO LTD
摘要:The present disclosure relates to synthesis and characterization of novel polymorphic forms of Cyclo (-His-Pro) (“CHPâ€?).

专利号:US-5543405-A
优先权日:1993-10-22
标题 :Composition and method for weight reduction and long term management of obesity
发明人：KEOWN WENDY J; FORD BETTY J; STODDARD SANDRA L
摘要:A weight reduction composition comprises a sympathomimetic agent and a mineral cation salt or chelate capable of enhancing carbohydrate metabolism, protein or fatty acid synthesis, retarding protein breakdown or lowering serum cholesterol levels such as trivalent and hexavalent chromium and vanadium salts and chelates. Preferred is a weight reduction composition containing ephedrine and chromium picolinate. This composition is presented in a variety of formulations, and is suitable for application to the reduction of weight of normal, slightly and grossly overweight humans.

专利号:US-2004146539-A1
优先权日:2003-01-24
标 题:Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits
发明人：GUPTA SHYAM K
摘要:I have discovered cosmetic or topical pharmaceutical compositions for external body part or organ slimming, firming, cellulite reduction, fat-reduction, and obesity control benefits that are in synergistic combination with benefits for the treatment of skin aging, skin wrinkles reduction, skin exfoliating, treatment of acne, treatment of rosacea, age-spots reduction, skin surface whitening, skin surface brightening striae distensae (stretch marks) reduction, treatment of pimples, treatment of skin infections and lesions, spider veins reduction, blood microcirculation (venous insufficiency) improvement, UVA/UVB protection of skin, and skin redness reduction. These compositions thus provide multiple combinations of skin and external body part or organ enhancement benefits that can be selective and specific for external body parts and organs such as face, chin, cheeks, arms, “love handlesâ€? in abdomen area, eye lids and eye zone, neck, breasts, thighs, and hips. These compositions include a body beneficial composition selected from certain nutraceutical, cosmetic, and pharmaceutical ingredients, a composition to promote collagen and elastin synthesis in the skin, and a cosmetically or pharmaceutically acceptable delivery ystem.