CAS: 1207175-73-2; Tert-Butyl (5-Bromo-3-Hydroxypyridin-2-yl)Carbamate

相似化合物

39903-01-0 902835-93-2 1534381-84-4

上下游产品

2-amino-3-hydroxypyridine tert-butyl dicarbonatedi-tert-butyl dicarbonate 2-amino-3-hydroxy-5-bromopyridine 2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-onecrizotinib (+/-)-PF023401066 lorlatinib

2-氨基-3-羟基吡啶置于吡啶,水,溴,三乙胺,Sodium Hydroxide体系中,用 二氯甲烷,1,2-二氯乙烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 23.0H,反应生成5-溴-3-羟基吡啶-2-基氨基甲酸叔丁酯
参考文献:A Novel Approach For The Synthesis Of Crizotinib Through The Key Chiral Alcohol Intermediate By Asymmetric Hydrogenation Using Highly Active Ir-Spiro-Pap Catalyst
标题:A Novel Approach For The Synthesis Of Crizotinib Through The Key Chiral Alcohol Intermediate By Asymmetric Hydrogenation Using Highly Active Ir-Spiro-Pap Catalyst
摘要:A Novel Approach For The Synthesis Of Crizotinib (1) Is Described. In Addition,New Efficient Procedures Have Been Developed For The Preparation Of (S)-1-(2,6-Dichloro-3-Fluorophenyl)Ethanol (2) And Tert-Butyl 4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-Pyrazol-1-yl)Piperidine-1-Carboxylate (4),The Key Intermediates Required For The Synthesis Of Crizotinib. (C) 2014 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetlet.2014.01.053