专利号:US-11548898-B2 优先权日:2017-07-06 标题 :Synthesis of halichondrins 发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI 权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD 摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).
专利号:US-10364220-B2 优先权日:2012-12-21 标题:Synthesis of succinimides and quaternary ammonium ions for use in making molecular sieves 发明人:SCHMITT KIRK D; ZUSHMA STEPHEN; BURTON ALLEN W 权利人:EXXONMOBIL CHEMICAL PATENTS INC 摘要:The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.
专利号:US-7943594-B2 优先权日:2002-07-10 标 题 :Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans 发明人:SEEBERGER PETER H; HEWITT MICHAEL C; SNYDER DANIEL A 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for GPI assembly. Yet another aspect of the invention relates to an automated method for the synthesis of GPIs and fragments thereof.
专利号:US-4339388-A 优先权日:1980-04-22 标题 :Synthesis of periplanone-B 发明人:STILL W CLARK 权利人:STILL W CLARK 摘要:A synthesis of periplanone-B, a female sex pheromone of the American cockroach, P. americana, is described. Novel compounds which are useful as intermediates in the synthesis of periplanone-B are described including the precursor alcohol, periplanol-B.
专利号:WO-8400363-A1 优先权日:1982-07-12 标题 :Synthesis of periplanone-b 发明人:STILL W CLARK 权利人:HERCULITE PRODUCTS INC 摘要:A synthesis of periplanone-B, a female sex pheromone of the American cockroach, P. americana. Novel compounds which are useful as intermediates in the synthesis of periplanone-B are described including the precursor alcohol, periplanol-B.
专利号:US-4311645-A 优先权日:1980-03-24 标 题 :Synthesis of SRS-active compounds 发明人:ROSENBERGER MICHAEL 权利人:HOFFMANN LA ROCHE 摘要:A chemical synthesis of an SRS-A active compound from the reaction product of 1-halo-2-octyne and the ether of 2-penten-4-yn-1-ol including intermediates in the synthesis, some of which being antagonists of SRS-A useful for treating allergic reactions.
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