CAS: 96946-42-8; (1R,1'R,2R,2'R)-2,2'-((Pentane-1,5-Diylbis(Oxy))Bis(3-Oxopropane-3,1-Diyl))Bis(1-(3,4-Dimethoxybenzyl)-6,7-Dimethoxy-2-Methyl-1,2,3,4-Tetrahydroisoquinolin-2-Ium) Benzenesulfonate

上下游产品

N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis-(R)-(-)-tetrahydropapaverine dioxalate Methyl benzenesulfonate N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis-(R)-(-)-tetrahydropapaverine 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3.4-dihydroisoquinoline hydr°Chloride

R-Tetrahydropapaverine N-Acetyl-L-Leucine置于草酰氯,水,Sodium Carbonate,Sodium Hydroxide体系中,用 二氯甲烷,水,甲苯,乙腈 作为反应溶剂,化学反应 78.0H,反应生成 苯磺顺阿曲库胺
参考文献:一种苯磺顺阿曲库铵的制备方法及其应用
标题:一种苯磺顺阿曲库铵的制备方法及其应用
摘要:本发明提供了一种苯磺顺阿曲库铵的制备方法及其应用,所述制备方法包括以下步骤:(1)将r‑四氢罂粟碱‑n‑乙酰‑l‑亮氨酸盐溶解,用碱性溶液调ph值,之后与3‑溴丙酸甲酯和碱混合反应,得到中间体a;(2)将步骤(1)得到的中间体a与碱混合反应,得到中间体b;(3)将步骤(2)得到的中间体b与甲基化试剂混合反应,得到中间体c;(4)将步骤(3)得到的中间体c,催化剂和脱水剂混合反应,得到所述苯磺顺阿曲库铵.本发明提供的制备方法生产过程安全,收率高,异构体少,最大单杂低.

专利信息

专利号:US-8063062-B2
优先权日:2006-12-20
标 题 :Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G; SHADID BELAL
权利人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; SHADID BELAL; SOLVAY PHARM BV
摘要:Embodiments of this invention relate to compounds having a combination of cannabinoid-CB 1 antagonism and cholinesterase inhibition, to pharmaceutical compositions comprising these compounds, to methods for preparing these compounds, methods for preparing novel intermediates useful for the synthesis of these compounds, and methods for preparing compositions comprising these compounds. The invention also relates to methods of treating Alzheimer's disease, cognitive disorders, memory disorders, dementia, attention deficit disorder, traumatic brain injury, drug dependence, addiction or substance abuse by administering a pharmaceutical composition comprising these compounds to a patient in need thereof. A compound with a combination of cannabinoid-CB 1 antagonism and cholinesterase inhibition is a compound of formula (1) n nwherein the symbols have the meanings given in the specification.

专利号:US-2024091733-A1
优先权日:2022-09-02
标题 :System of modular kits to produce chemical targets of interest
发明人：CHOI EUGENE; RAPP KERSTEN; HAMMERSMITH GREG; CREGGER BRIAN
权利人:ODH IP CORP
摘要:This disclosure provides systems and methods for the on-demand synthesis, separation, purification and formulation of chemicals, and particularly for the on-demand production of pharmaceutical products. More particularly, the disclosure provides continuous-flow on-demand systems, comprising one or more reagent holding/dispensing containers, continuous-flow chemical synthesis modules and/or one or more separation, crystallization, filtration, wash and/or formulation modules, additionally comprising automated detection systems and methods for monitoring reagents, products and processing parameters and automated control systems and methods for controlling processing conditions and parameters.

专利号:WO-2023039313-A1
优先权日:2021-09-07
标题:Systems and methods for contactless detection of chemicals in a container
发明人：RAMENZANI MAHDI; SAMUEL JONATHAN; BREZICKI GORDON
权利人:ON DEMAND PHARMACEUTICALS INC
摘要:This disclosure provides systems and methods for the qualitative and/or quantitative touchless measurement of chemicals contained within a container. The container and touchless detection system may be incorporated into an on-demand continuous-flow synthesis apparatus for production of chemicals, and particularly for the on-demand production of pharmaceutical products.

专利号:WO-2023086696-A2
优先权日:2021-11-10
标 题:Apparatus and methods for continuous flow synthesis of cisatracurium

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:CN-115124466-B
优先权日:2022-07-19
标题 :A kind of synthesis method of tetrahydropapaverine hydrochloride