CAS: 916326-10-8; Ethyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Nicotinate
该化合物是一种化学化合物,其特点是其独特的结构,包括一个含有硝基丁酸和含有二氧基的二氧基化合物组;该化合物的特点是作为二氧基环的一部分的原生物原子,有助于其在有机合成中的潜在反应性和效用,特别是在黄化学中;乙酯组的存在增强了其在有机溶剂中的溶解性,使之适合于医药化学和材料科学的各种应用;该化合物可能由于与硝基酸有关的硝基丁酸成分,而具有有趣的生物特性,该成分是重要的共生酶的前体;此外,阻塞的原生物质组可以影响化合物的再活性,使其成为合成更复杂的分子中有价值的中间体;
- 英文名称Ethyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Nicotinate
- 中文名称5-(4,4,5,5-四甲基-1,3,2-二氧杂硼烷-2-基)烟酸乙酯
- IUPAC名称ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate
- 其它别名3-(乙氧基甲酰基)吡啶-5-硼酸频哪醇酯; 5-(Ethoxycarbonyl)Pyridine-3-Boronic Acid Pinacol Ester
- CAS编号916326-10-8
- MFCD编号:MFCD04117940
- EINECS号:864-036-6
- 分子式:C14H20BNO4分子量:277.13
- 产品CID: 1953848
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物
相似化合物
875781-62-7 848093-29-8 1025718-91-5MSDS等安全信息
欧盟法规
C&L通报上下游产品
ethyl 5-bromo-3-pyridinecarboxylate bis(pinacol)diborane 3-pyridinecarboxylic acid ethyl ester ethyl 5-[5-(4-{[2-(trifluoromethyl)phenyl]oxy}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]pyridine-3-carboxylate ethyl 6'-{[(ethylamino)carbonyl]amino}-4'-(4-phenyl-1,3-thiazol-2-yl)-3,3'-bipyridine-5-carboxylate 5-(6-(3-(methylsulfonyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyridine-3-carboxylic acid ethyl 5-{2-[(3-chloro-4-fluorophenyl)amino]-4-(methylsulfonyl)pyrimidin-5-yl}pyridine-3-carboxylate合成工艺路线路线简述
📜烟酸乙酯,联硼酸频那醇酯置于(1,5-Cyclooctadiene)(Methoxy)Iridium(I) Dimer,4,4'-二叔丁基-2,2'-二吡啶体系中,用 四氢呋喃 作为反应溶剂,化学反应 18.0H,反应生成 3-(乙氧基甲酰基)吡啶-5-硼酸频哪醇酯
参考文献:芳烃的区域选择性转化为n-芳基-1,2,3-三唑用c h硼化
标题:芳烃的区域选择性转化为n-芳基-1,2,3-三唑用c h硼化
摘要:的单釜协议用于合成ñ-芳基的1,2,3-三唑从芳烃通过铱催化的ç ħ硼化/铜催化的叠氮化/击序列进行说明.发现1Mol%的cu(otf)2有效地催化了叠氮化和点击反应.1,2,3-三唑部分在化学上重要的未活化分子的后期化学选择性安装证明了该方法的适用性.
DOI:10.1002/chem.201403021
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
专利号:US-7541367-B2
优先权日:2005-05-31
标 题 :3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
发明人：CHIU GEORGE; CONNOLLY PETER J; EMANUEL STUART; HUANG SHENLIN; LI SHENGJIAN; LIN RONGHUI; LU YANHUA; MIDDLETON STEVEN A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.
