CAS: 79-84-5; Thiophene-2-Sulfonic Acid

上下游产品

2-thienyl hexyl ketone sulfuric acid 1-thiophen-2-yl-propan-1-one 2-methyl-1-thiophen-2-yl-propan-1-one thiophene thiophene-2-sulfonyl chloride

专利信息

专利号:WO-9639413-A1
优先权日:1995-05-23
标题 :Methods and compounds for the synthesis of oligonucleotides and the oligonucleotides thereby produced
发明人：IYER RADHAKRISHNAN P; YU DONG; AGRAWAL SUDHIR; TAN WEITIAN; DEVLIN THERESA; HABUS IVAN
权利人:HYBRIDON INC; IYER RADHAKRISHNAN P; YU DONG; AGRAWAL SUDHIR; TAN WEITIAN; DEVLIN THERESA; HABUS IVAN
摘要:The present invention provides new mononucleotide synthons useful in the synthesis of oligonucleotides having from one to all P-chiral centers that are predominantly and independently in the R or S configuration. The invention also provides methods of synthesizing these synthons, methods of synthesizing oligonucleotides having from one to all P-chiral centers predominantly and independently in the R or S configuration, and such oligonucleotides. Oligonucleotides synthesized with the novel synthons are useful for modulating nucleic acid expression, both in vitro and in vivo, as well as in traditional hybridization assays.

专利号:US-6117993-A
优先权日:1995-05-23
标题 :Synthons for oligonucleotide synthesis
发明人：IYER RADHAKRISHNAN P; YU DONG; GUO MAO-JUN; AGRAWAL SUDHIR
权利人:HYBRIDON INC
摘要:The invention provides new reagents and processes for synthesizing oligonucleotides, including stereoselective oligonucleotide synthesis. In a first aspect, the invention provides novel monomer synthons for the synthesis of oligonucleotides. Monomer synthons according to this aspect of the invention are useful in the synthesis of oligonucleotides and can be used in place of the well known beta-cyanoethyl phosphoramidite monomer synthon in the phosphoramidite synthesis procedure. Certain monomer synthons according to this aspect of the invention are useful in this procedure for producing oligonucleotides having defined stereochemistry. n In a second aspect, the invention provides processes for synthesizing monomer synthons according to the invention, including diastereomerically enriched or purified monomer synthons. In the processes according to this aspect of the invention, the chemical reactions are stereoretentive so that the products of each reaction retain the same stereoconfiguration as their precursor reagent. n In a third aspect, the invention provides processes for synthesizing oligonucleotides using the well known phosphoramidite approach. In the processes according to this aspect of the invention, any of the monomer synthons according to the invention is used in place of the conventional beta-cyanoethyl phosphoramidite.

专利号:EP-0836612-B1
优先权日:1995-05-23
标 题 :Novel synthons for stereoselective oligonucleotide synthesis
发明人：IYER RADHAKRISHNAN P; DEVLIN THERESA; HABUS IVAN; YU DONG; AGRAWAL SUDHIR
权利人:HYBRIDON INC
摘要:The invention provides new reagents and processes for synthesizing oligonucleotides, including stereoselective oligonucleotide synthesis. In a first aspect, the invention provides novel monomer synthons for the synthesis of oligonucleotides. Monomer synthons according to this aspect of the invention are useful in the synthesis of oligonucleotides and can be used in place of the well known beta-cyanoethyl phosphoramidite monomer synthon in the phosphoramidite synthesis procedure. Certain monomer synthons according to this aspect of the invention are useful in this procedure for producing oligonucleotides having defined stereochemistry. In a second aspect, the invention provides processes for synthesizing monomer synthons according to the invention, including diastereomerically enriched or purified monomer synthons. In the processes according to this aspect of the invention, the chemical reactions are stereoretentive so that the products of each reaction retain the same stereoconfiguration as their precursor reagent. In a third aspect, the invention provides processes for synthesizing oligonucleotides using the well known phosphoramidite approach. In the processes according to this aspect of the invention, any of the monomer synthons according to the invention is used in place of the conventional beta-cyanoethyl phosphoramidite.

专利号:US-5306638-A
优先权日:1992-03-20
标题 :Amine additive assisted enzymatic esterification of 1,2-diol monosulfonates
发明人：BOAZ NEIL W
权利人:EASTMAN KODAK CO
摘要:A process has been developed for the enzymatic esterification of 1,2-diol monosulfonates comprising contacting an ester; a 1,2-diol monosulfonate; an enzyme derived from a microorganism or animal organ which has stereoselective activity to asymmetrically esterify said 1,2-diol monosulfonate; in the presence of a nonhydroxylic organic solvent and an amine additive of the general formula R32R4N, wherein R3 may be the same or different and is selected from hydrogen or a straight or branched C1-C20 alkyl; and R4 is a straight or branched C1-C20 alkyl; or an unsubstituted or substituted C3-C20 aryl or heteroaryl group (with saisd substituent selected from C1-C4 alkyl, halogen, or C1-C4 alkoxy, and said hetero atom selected from nitrogen, sulfur, or oxygen); to produce a mixture of enantiomerically enriched unreacted 1,2-diol monosulfonate and the corresponding antipodal enantiomerically enriched ester. The resulting enantiomerically enriched products are useful chemical intermediates that may be employed in the synthesis of pharmaceutical and agricultural chemicals.

专利号:US-5750674-A
优先权日:1995-05-23
标题:Methods and compounds for the stereoselective enrichment of oligonucleotide diastereomers and oligonucleotides thereby produced
发明人：IYER RADHAKRISHNAN P; YU DONG; AGRAWAL SUDHIR; TAN WEITIAN
权利人:HYBRIDON INC
摘要:The present invention provides new mononucleotide synthons useful in the synthesis of oligonucleotides having from one to all P-chiral centers that are predominantly and independently in the R or S configuration. The invention also provides methods of synthesizing these synthons, methods of synthesizing oligonucleotides having from one to all P-chiral centers predominantly and independently in the R or S configuration, and such oligonucleotides. Oligonucleotides synthesized with the novel synthons are useful for modulating nucleic acid expression, both in vitro and in vivo, as well as in traditional hybridization assays.

专利号:US-6005103-A
优先权日:1993-11-19
标题 :Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.