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CAS号76-02-8 三氯乙酰氯 | CAS号544-00-3 二异戊胺 | CAS号598-99-2 三氯乙酸甲酯 | CAS号75-87-6 三氯乙醛 | CAS号302-17-0 水合氯醛 | CAS号64-19-7 冰醋酸 | CAS号108-24-7 乙酸酐 | CAS号127-18-4 四氯乙烯 | CAS号116-16-5 六氯丙酮 | CAS号6135-29-1 trichloromethyl... | CAS号104756-60-7 (9ci)-1-(二氯乙酰基)... | CAS号497-25-6 2-恶唑烷酮 | CAS号25436-07-1 三甲基硅基三氯乙酸 | CAS号584-87-2 3-甲酰基-4-羟基苯甲酸 | CAS号326-66-9 4-溴-2-氟乙酰苯胺 | CAS号598-99-2 三氯乙酸甲酯 | CAS号824-42-0 3-甲基水杨醛 | CAS号15174-69-3 3-甲基-4-羟基苯甲醛 | CAS号14789-75-4 2,4-Cyclohexadi... | CAS号1456-20-8 2-phenyl-5-(tri...

三氯乙醛置于tetra-N-Butylammonium Tribromide,Potassium Bromide体系中,用 水,溶剂黄146 作为反应溶剂,化学反应生成 三氯乙酸
参考文献:三溴化四丁基铵氧化脂肪醛的动力学和机理
标题:三溴化四丁基铵氧化脂肪醛的动力学和机理
摘要:三溴化四丁基铵 (Tbatb) 在乙酸水溶液中氧化六种脂肪醛,形成相应的羧酸.就 Tbatb 和醛而言,该反应是一级反应.氘化乙醛 (Mecdo) 的氧化表明存在显着的动力学同位素效应 (Kh/kd = 5.92 At 298 K).添加四丁基氯化铵对反应速率没有影响.已提出三溴化物离子作为活性氧化物质.速率常数与 Taft 的 σ* 值密切相关,反应常数为负.已经提出了在速率确定步骤中涉及氢化物离子从醛水合物转移到氧化剂的机制.© 2001 John Wiley & Sons,Inc. Int J Chem Kinet 33: 390-395,2001
DOI:10.1002/kin.1033

专利信息

专利号:US-2025313590-A1
优先权日:2024-03-16
标题:Phosphoramidite morpholino monomers towards synthesis/convergent synthesis of PMO, TMO, their chimera oligos in 5 prime to 3 prime direction
发明人：SINHA SURAJIT; GHOSH ATANU; BANERJEE ARPAN
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:The present invention relates to 5′-morpholino amidite monomers as 5′-CE/5′- t Bu phosphoramidite morpholino monomers (2) and process chemistry for the efficient synthesis of N-Trityl or monomethoxytrityl (MMTr)-protected 5′-morpholino amidite monomers and their use in the synthesis of phosphorodiamidate morpholino oligonucleotides (PMO), thiophosphoramidate morpholino oligonucleotides (TMO) and their chimeras which can be used for antisense technology or in general oligonucleotides related research.

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:WO-2025044766-A1
优先权日:2023-08-31
标题:Use of silicon dioxide microspheres in synthesis of ultra-long oligonucleotide and method for synthesizing ultra-long oligonucleotide
发明人：SHI YONGYONG; ZHANG MANCANG; WANG LIBING; GAO PANPAN; FANG JUN
权利人:UNIV SHANGHAI JIAOTONG; SHANGHAI DYNEGENE TECH CO LTD
摘要:The present invention relates to the technical field of oligonucleotide synthesis. Disclosed are the use of silicon dioxide microspheres in the synthesis of an ultra-long oligonucleotide and a method for synthesizing an ultra-long oligonucleotide, wherein the silicon dioxide microspheres have a specific surface area of less than 1 m2/g, and preferably, the silicon dioxide microspheres have modification groups on the surface. The method for synthesizing an ultra-long oligonucleotide comprises: performing a coupling reaction on a nucleoside phosphoramidite synthesis unit using the silicon dioxide microspheres having modification groups on the surface as carriers under coupling reaction conditions. The prepared carriers can be used to prepare an ultra-long oligonucleotide.

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.