CAS: 74244-17-0; Boc-Asp-Nh2

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200335-40-6 200335-41-7 200260-37-3

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CAS号1070-19-5 Carbonazidic ac... | CAS号28057-52-5 (S)-3,4-二氨基-4-氧代丁酸

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-4212795-A
优先权日:1978-11-13
标题:Cyclization of peptides
发明人：HUGHES JOHN L; LIU ROBERT C; SEYLER JAY K
权利人:ARMOUR PHARMA
摘要:The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing two cysteine moieties, each of which is protected by an n-alkylthio group, or when one of such moieties is in an amino terminal position, this one moiety may be protected by a cysteine group while the other is protected by an n-alkylthio group, and placing such intermediate peptide in a solution substantially free of oxygen and preferably at a pH of from 5 to 10 until rearrangement has taken place, to yield a cyclic disulfide peptide. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.

专利号:US-4033940-A
优先权日:1975-11-12
标 题:Cyclization of peptides
发明人：HUGHES JOHN L; SEYLER JAY K; LIU ROBERT C
权利人:ARMOUR PHARMA
摘要:The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing an amino terminal cystine residue and a cysteine residue located in a position within the amino acid sequence, to give a desired peptide, and placing such intermediate peptide in a solution substantially free of oxygen at a pH of from about 5 to 10 until rearrangement takes place to yield a cyclic disulfide peptide and to displace a molecule of cysteine from the amino terminal cysteine residue. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.

专利号:US-4089821-A
优先权日:1976-03-31
标 题:Synthesis of peptide amides
发明人：ENKOJI TAKASHI; SKIBBE MARTIN O
权利人:ARMOUR PHARMA
摘要:Peptide amides having biological activity and resin peptide amides useful in the preparation of peptides having biological activity, particularly such peptides containing the structure in which R is divinylbenzene crosslinked polystyrene and Bz is benzyl, p-methoxybenzyl, p-chlorobenzyl, p-nitrobenzyl, or benzhydryl, and in which phe and glu are residues of the amino acids phenylalanine and glutamic acid; and processes for preparing such peptide amides.

专利号:US-3592836-A
优先权日:1966-12-23
标 题:Aryloxycarbonyl fluorides and amino acids and their production
发明人：UGI IVAR; KLAUKE ERICH; SCHNABEL EUGEN; HOFFMANN PETER
权利人:BAYER AG
摘要:ARYLOXYCARBONYL FLUORIDES SUCH AS FURFURYLOXYCARBONYL-, P-METHOXYBENZYLOXYCARBONYL- AND TRIMETHOXYBENZYLOXYCARBONYL-FLUORIDES ARE PROVIDED WHICH ARE USEFUL AS INTERMEDIATES FOR AMINO ACID DERIVATIVES AND ARE OBTAINED FROM CARBONYL-FLUORIDE CHLORIDE BY REACTION WITH THE APPROPRIATE ALCOHOL. THE AMINO ACID DERIVATIVES OF SUCH CARBONYL-FLUORIDES ARE BUILT UP THROUGH ACYLATION OF AMINO ACIDS THEREWITH. THESE AMINO ACID DERIVATIVES ARE USEFUL AS INTERMEDIATES FOR THE SYNTHESIS OF POLYPEPTIDES. THE REACTION OF CARBONYLCHLORIDE-FLUORIDE IS ADVANTAGEOUSLY CARRIED OUT AT TEMPERATURES OF 0 TO 70*C. IN AN INERT SOLVENT AND IN THE PRESENCE OF AN ACID-BINDING AGENT. THE AMINO ACID DERIVATIVES ARE FORMED AT TEMPERATURES BETWEEN +20 AND -20*C. ALSO IN THE PRESENCE OF AN ACID-BINDING AGENT. IMINO ACIDS CAN BE USED IN PLACE OF AMINO ACIDS. THE AMINO- OR IMINO-ACID DERIVATIVES OR ESTERS ARE ADVANTAGEOUSLY PREPARED AT CONSTANT. CONTROLLED PH VALUES, PREFERABLY BY THE USE OF AUTOMATIC PH CONTROL EQUIPMENT.

专利号:GB-1586974-A
优先权日:1977-07-04
标 题:Synthesis of peptide amides