CAS: 7151-76-0; 4-(Methylsulfonamido)Benzoic Acid

上下游产品

methyl 4-(methanesulfonylamino)benzoate 4-amino-benzoic acid methanesulfonyl chloride 4-methoxycarbonyl aniline 4-Methanesulfonylamino-N-{2-[2-(5-methyl-1H-imidazol-4-yl)-ethylamino]-ethyl}-benzamide N-{4-[4-(1-Methyl-1H-benzoimidazol-2-yl)-piperazine-1-carbonyl]-phenyl}-methanesulfonamide N-methyl-N-[2-[methyl(quinolin-2-yl)amino]ethyl]-4-[(methylsulfonyl)amino]benzamide ethyl>-4-benzamideN-methyl-N-2-ethyl-4-(methylsulfonyl)aminobenzamide

📜4-(甲基磺酰胺)苯甲酸甲酯置于氢氧化钾体系中,用 甲醇 作为反应溶剂,化学反应 24.0H,以89%的收率获得产物4-甲磺酰氨基苯甲酸
参考文献:Synthesis And Protein Kinase C Inhibitory Activities Of Balanol Analogues With Modification Of 4-Hydroxybenzamido Moiety
标题:Synthesis And Protein Kinase C Inhibitory Activities Of Balanol Analogues With Modification Of 4-Hydroxybenzamido Moiety
摘要:A Series Of Racemic Balanol Analogues With Modification Of The Benzamido Moiety Of Balanol Have Been Synthesized And Evaluated For Their Inhibitory Activities Against Human Protein Kinase C Isozymes (Pkc-Alpha,-Beta I,-Beta Ii,-Gamma,-Delta,-Epsilon,And-Eta). The Structural Modification Includes Replacement Of The 4-Hydroxyphenyl Group With Variously Substituted Phenyl Rings,Substitution Of The Amide Linkage With A Sulfonamide Or An Ester,And Replacement Of The 4-Hydroxyphenyl Substructure With A Hydroxyl Substituted Indole Or A Hydroxybenzyl Group. In General,These Analogues Were Found To Be Less Potent Than Balanol,But A Number Of Analogues Were Identified With Improved Isozyme Selectivity. The Structure-Activity Relationship Studies Of These Analogues Also Indicated That (1) The Optimal General Pkc Inhibition Requires A Free 4-Hydroxyl Group In The Benzamido Portion Of The Molecule,(2) The Amide Linkage Of The Benzamido Moiety Is Important For Pkc Inhibition,And (3) The Conformation Associated With The Benzamido Moiety Seems To Have A Profound Effect On Pkc Inhibition. The Requirement Of A Free 4-Hydroxyl Group In Conjunction With An Appropriate Conformation Of The Benzamido Moiety For Optimal Pkc Inhibition Suggests That The 4-Hydroxyphenyl Group May Be Involved In A Specific Inhibitor-Enzyme Interaction Important For Pkc Inhibition. (C) 1997 Elsevier Science Ltd.
DOI:10.1016/s0968-0896(97)00125-9