CAS: 71-68-1; Hydromorphone Hydrochloride
- 英文名称Hydromorphone Hydrochloride
- 中文名称盐酸氢吗啡酮
- IUPAC名称(4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride
- 其它别名Morphinan-6-one,4,5-epoxy-3-hydroxy-17-methyl-, hydr°Chloride, (5a)- (9CI); Morphinan-6-one, 4,5a-epoxy-3-hydroxy-17-methyl-,hydr°Chloride (8CI); Morphinone, dihydro-, hydr°Chloride (6CI); 4,5-Epoxy-3-hydroxy-N-methyl-6-oxomorphinan hydr°Chloride; Dihydromorphinonehydr°Chloride; Dilaudid; Dilaudid hydr°Chloride; Hydromorphodone; Hydromorphonehydr°Chloride; Hymorphan; Laudicon; Palladone
- CAS编号71-68-1
- MFCD编号:MFCD03427563
- EINECS号:200-762-6
- FDA UNII编号:L960UP2KRW
- 分子式:C17H20ClNO3分子量:321.8
- 产品CID: 1706484
- 产品分类有机原料 → 生物碱及其衍生物 → 吗啡烷
物理性质
- 熔点>280°C (分解)
- 沸点280 °C (分解)>>280 °C (分解)
- 闪点241.4 °C
- 密度1.1451 (粗估)
- PH:D25 -133°
- PSA:49.77
- LogP:2.3702
- 折射率1.6470 (估算)
- 蒸汽压1.88E-11 mmHg at 25 °C
- 溶解性水: >10 mg/mL
- 外观形态结晶性固体
- 储存条件2-8°C
- 产品应用2,3-二氯-6-三氟甲基-4-硝基甲苯(71-68-1)为吗啡的衍生物,主要作用于μ受体.镇痛效力为吗啡的8倍.用于中度至重度疼痛的止痛,不良反应及依赖潜力同吗啡.
- 性质描述2,3-二氯-6-三氟甲基-4-硝基甲苯(71-68-1)为白色或近白色结晶性细粉末,无臭,味苦,溶于水(1:3),难溶于乙醇;几乎不溶于乙醚.注射液PH为3.5~5.5.储存条件:2-8°C溶解度:H2O >10 mg/mL
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(经口)
特定目标器官毒性 - 单次接触 类别3
水生慢性毒性 类别3
生殖毒性 类别2
急性毒性 类别3(吸入)
急性毒性 类别3(经口)
皮肤致敏 类别1 - 警示词Warning(警告)
- 危险描述H302 |吞咽有害.
H336 |可能引起嗜睡或头晕.
H412 |对水生生物有害并具有长期持续影响.
H361 |怀疑对生育能力或胎儿造成损害.
H331 |吸入会中毒.
H301 |吞咽会中毒.
H317 |可能引起皮肤过敏反应. - 防范说明P301+P312+P330
- 危险等级6.1(a)
- UN编号UN 1230 3/PG 2
- 危险品标志Xn
- 包装等级II
- 安全声明16-36/37-45
- 危险类别码22
- WGK Germany3
欧盟法规
ECHA物质ECHA物质C&L通报REACH预注册上下游产品
Hydr°Codone hydromorphone Dihydromorphine hydr°Chloride (-)-tetrahydrothebainenorbinaltorphimine dihydroisomorphine 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-hydroxy-17-methylpyrido[2',3':6,7]morphinan hydromorphone合成工艺路线路线简述
📜二氢可待因酮置于盐酸体系中,用 乙醇,水 作为反应溶剂,以75%的收率获得产物盐酸氢吗啡酮
参考文献: A Method Of Preparation Of 4,5Alpha-Epoxy-6-Oxomorphinan Derivatives[fr] Methode De Preparation De Derives De 4,5 Dollar G(A)-Epoxy-6-Oxomorphinane
标题: A Method Of Preparation Of 4,5Alpha-Epoxy-6-Oxomorphinan Derivatives[fr] Methode De Preparation De Derives De 4,5 Dollar G(A)-Epoxy-6-Oxomorphinane
摘要:一种制备4,5α-环氧-6-酮吗啡衍生物的方法,其中r1为氢,甲基或乙基,R2为氢,甲基,环丁基甲基或苄基,在该方法中,式(II)化合物,在其中r1和r2如与化合物(i)相对应定义,存在于含有铂族金属至少两种元素的混合催化剂的情况下,异构化为式(i)化合物.该方法以产率和低杂质含量提供产品.
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2905122000-异丙醇
2907210001-间苯二酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6589960-B2
优先权日:1999-11-09
标题 :Hydromorphone and hydrocodone compositions and methods for their synthesis
发明人：HARCLERODE WILLIAM H; GAULT ROBERT; SANDISON MARK D
权利人:ABBOTT LAB
摘要:A method for the preparation of a ketone from a narcotic alkaloid having an allyl alcohol moiety is disclosed. The method includes mixing the narcotic alkaloid with an acid in the presence of a catalyst wherein the method is carried out in the substantial absence of hydrogen gas. The method is useful for preparing hydromorphone and hydrocodone compositions having novel impurity profiles. Compositions comprising hydromorphone and hydrocodone are also disclosed.
专利号:US-2024043447-A1
优先权日:2020-11-13
标 题 :Synthesis of hydromorphone base
发明人：MARQUILLAS OLONDRIZ FRANCISCO DE ASÃ?S; BESSA BELLMUNT JORGE; DE LEÓN MARTÃ?N ANTONIO ABELINO
权利人:FERRER INT
摘要:Hydromorphone hydrochloride (I·HCl) is converted into hydromorphone base (I) via hydromorphone monohydrate (I·H2O).
专利号:WO-2022101408-A1
优先权日:2020-11-13
标 题:Synthesis of hydromorphone base
专利号:EP-4244226-A1
优先权日:2020-11-13
标 题 :Synthesis of hydromorphone base
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1007/s12630-011-9556-9
摘要:Forero M, Neira VM, Heikkila AJ, Paul JE. Continuous lumbar transversus abdominis plane block may spread to supraumbilical dermatomes. Journal canadien d'anesthésie. 2011 Jul 12;58(10):948. doi: 10.1007/s12630-011-9556-9.
参考文献:10.1007/s00404-011-1999-2
摘要:Nash K, Feinglass J, Zei C, Lu G, Mengesha B, Lewicky-Gaupp C, Lin A. Robotic-assisted laparoscopic myomectomy versus abdominal myomectomy: a comparative analysis of surgical outcomes and costs. Archives of Gynecology and Obstetrics. 2011 Jul 22;285(2):435–40. doi: 10.1007/s00404-011-1999-2.
📝 需求与反馈
尽可能描述清楚需求与问题信息
