CAS: 6640-27-3; 2-Chloro-4-Methylphenol

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CAS号106-44-5 对甲酚 | CAS号622-60-6 4-甲基苯乙醚 | CAS号22002-44-4 3-氯-4-甲氧基甲苯 | CAS号1121-70-6 sodium p-cresolate | CAS号5707-04-0 苯硒酰氯 | CAS号615-65-6 2-氯-4-甲基苯胺 | CAS号108-41-8 间氯甲苯 | CAS号7791-25-5 磺酰氯 | CAS号7647-01-0 盐酸 | CAS号68758-67-8 2-chloro-1-etho... | CAS号452-86-8 4-甲基邻苯二酚 | CAS号22002-30-8 2-chloro-6-(hyd... | CAS号95-75-0 3,4-二氯甲苯 | CAS号2420-16-8 3-氯-4-羟基苯甲醛 | CAS号70264-59-4 2,4-dichloro-4-... | CAS号2432-12-4 2,6-二氯对甲酚 | CAS号854211-66-8 3,3'-dichloro-2... | CAS号22002-44-4 3-氯-4-甲氧基甲苯 | CAS号10568-14-6 4-methyl-2-(4-m... | CAS号6625-63-4 2-chloro-6-[[(3...

3-氯-4-甲氧基甲苯置于三溴化硼体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,反应生成 2-氯-4-甲基苯酚
参考文献:氘代苯并吡喃衍生物的合成作为具有改善的药代动力学性质的选择性cox-2抑制剂.
标题:氘代苯并吡喃衍生物的合成作为具有改善的药代动力学性质的选择性cox-2抑制剂.
摘要:我们设计了一系列专门氘化的苯并吡喃类似物作为新的cox-2抑制剂,旨在改善其药代动力学特性.如预期的那样,氘代化合物保留了对cox-2的效力和选择性.与它们的非氘代同类物相比,新分子在大鼠中具有改善的药代动力学特征.最重要的是,新化合物在几种小鼠炎症和疼痛模型中均显示出药效学功效.苯并吡喃衍生物被分离成它们的对映异构体,并且发现该活性与s-异构体有关.为了简化所需s异构体的合成,开发了有机催化的不对称多米诺oxa-Michael /羟醛缩合反应用于制备.
DOI:10.1021/ml500299Q

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-4161609-A
优先权日:1977-09-14
标题:Synthesis of carboxylic acid esters
发明人：CRAMER RICHARD D
权利人:DU PONT
摘要:A method is provided for converting a carboxylic acid amide to a carboxylic acid ester by reacting a vaporized mixture of the amide and an aliphatic alcohol or a phenol in the presence of a suitable catalyst at temperatures of from 100 DEG C. to 400 DEG C. The process is especially useful for the conversion of methacrylamide to methyl methacrylate.

专利号:EP-0830136-B1
优先权日:1995-03-07
标 题:New cryptophycins from synthesis
发明人：MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; HEMSCHEIDT THOMAS K; GOLAKOTI TRIMURTULU
权利人:UNIV HAWAII; UNIV WAYNE STATE
摘要:Novel cryptophycin compounds are disclosed, together with methods of producing cryptophycins by total synthesis and methods for the use of such cryptophycins in pharmaceuticals to inhibit the proliferation of mammalian cells and to treat neoplasia.

专利号:US-6013626-A
优先权日:1993-12-21
标题 :Cryptophycins from synthesis
发明人：MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; GOLAKOTI TRIMURTULU; HEMSCHEIDT THOMAS K
权利人:UNIV HAWAII; UNIV WAYNE STATE
摘要:A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.

专利号:US-5880146-A
优先权日:1995-06-07
标 题 :Inhibition of IL-12-induced IFN-γ synthesis by specific bis-phenol compounds as a method of immune modulation
发明人：GILLIES STEPHEN D; WESOLOWSKI JOHN
权利人:FUJI IMMUNOPHARMACEUTICALS COR
摘要:Disclosed are chemical agents for modulating certain cellular immune reactions that can lead to autoimmune disorders. By specific modulation, harmful immune reactions can be lessened in severity or even prevented without resorting to potentially dangerous general immune suppression. The described chemical agents inhibit IL-12 induction of the secretion of key immune modulators. The described chemical agents are specific inhibitors of IL-12 induced Th1 immune response.

专利号:US-4105668-A
优先权日:1975-01-10
标题:Process for 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam
发明人：NAKANISHI SUSUMU
权利人:PFIZER
摘要:Certain 6-amino-2,2-dimethyl-3-(1-substituted tetrazol-5-yl)penam and 6-(protected amino)-2,2-dimethyl-3-(1-substituted tetrazolyl-5-yl)penam compounds react with hydrogen fluoride to produce 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam, a useful intermediate for the synthesis of antibacterial agents.