CAS: 636-97-5; 4-Nitrobenzohydrazide

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CAS号99-77-4 对硝基苯甲酸乙酯 | CAS号619-50-1 4-硝基苯甲酸甲酯 | CAS号122-04-3 对硝基苯甲酰氯 | CAS号62-23-7 对硝基苯甲酸 | CAS号1262524-08-2 1,4-bis(4-nitro... | CAS号43038-36-4 4-氰基苯肼 | CAS号98-95-3 硝基苯 | CAS号1037-31-6 Benzoic acid, 4... | CAS号106710-57-0 (1E,3E)-2-methy... | CAS号106710-45-6 3-[2-(4-nitrobe... | CAS号50677-30-0 2-(氯甲基)-5-(4-硝基... | CAS号147801-96-5 1-[2-(4-nitrobe... | CAS号41125-77-3 5-(4-硝基苯基)-1,3,... | CAS号19756-72-0 4-硝基苯甲酸叔丁酯 | CAS号62-23-7 对硝基苯甲酸 | CAS号22816-00-8 1-Acetyl-2-(4-n... | CAS号35219-13-7 4-(1,3,4-噁二唑-2-基)苯胺 | CAS号555-16-8 对硝基苯甲醛

📜4-硝基苯甲酰氯置于吡啶,一水合肼体系中,用 乙醇 作为反应溶剂,化学反应 3.5H,反应生成 4-硝基苯酰肼
参考文献:Histone Deacetylase 3‐directed Protacs Have Anti‐inflammatory Potential By Blocking Polarization Of M0‐like Into M1‐like Macrophages
标题:Histone Deacetylase 3‐directed Protacs Have Anti‐inflammatory Potential By Blocking Polarization Of M0‐like Into M1‐like Macrophages
摘要:摘要巨噬细胞极化在炎症过程中起着至关重要的作用.组蛋白去乙酰化酶3(hdac3)具有不依赖于去乙酰化酶的功能,它能激活脂多糖刺激的m1样巨噬细胞中的促炎基因表达,而传统的小分子hdac3抑制剂无法阻断这种功能.在这里,我们采用了蛋白水解靶向嵌合体(protac)技术来靶向 Hdac3 的去乙酰化酶依赖性功能.我们开发出了一种强效且具有选择性的 Hdac3 定向 Protac P7,它能在低微摩浓度下诱导 Thp-1 细胞和人类原代巨噬细胞中的 Hdac3 几乎完全降解.p7 能增加 Thp-1 衍生的 M1 样巨噬细胞的抗炎细胞因子分泌.重要的是,P7 能减少源自人类原代巨噬细胞的 M1 样巨噬细胞中促炎细胞因子的分泌.这可以通过观测到的巨噬细胞从 M0 样巨噬细胞极化为 M1 样巨噬细胞的抑制作用来解释.总之,我们证明了 Hdac3 导向的 Protac P7 具有抗炎活性并能阻断巨噬细胞极化,从而证明这种分子机制可以用小分子疗法来靶向治疗.
DOI:10.1002/anie.202310059

专利信息

专利号:WO-2011110511-A1
优先权日:2010-03-11
标题:Spect imaging agents of amyloid plaques
发明人：SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
权利人:Bayer Pharma AG; SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
摘要:The invention relates to novel iodine -radiolabeled compounds useful for diagnosing Alzheimer's desease, to respective novel precursors for the synthesis of such compounds, and to the process of manufacturing said imaging agent of the following Formula (I), wherein Q is a six membered aromatic ring, either carbocycle or heterocycle with one N- atom, wherein X 1 , X 2 , X 3 , X 4 and X 5 are independently selected from N or C, and wherein zero or one of X 1 ( X 2 , X 3 , X 4 or X 5 is N and the remaining ones are C; A is either Sn(alkyl)3, I, l-123, l-124, l-125, l-131, Br; wherein alkyl comprises methyl, ethyl, propyl, butyl, pentyl and hexyl, Y is C or N; with the proviso that if X 1 ( X 2 , X 3 , X 4 or X 5 has the meaning of N, substitution by A in that position is excluded; or a pharmaceutically acceptable salt thereof.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2010172836-A1
优先权日:2008-12-31
标题 :Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof