CAS: 63335-25-1; 1-(2,6-Dihydroxyphenyl)-9-(3,4-Dihydroxyphenyl)Nonan-1-One
该化合物是一种生物活性第二代代代谢物,被归类为日记单体,主要与Myristica malabarica和相关物种隔离,具有显著的抗微生物,抗风和抗炎特性,使其在制药和农用化学研究中成为兴趣的复合体.在结构上,它具有独特的活性副代谢物核心,具有长的脂质侧链,有助于其脂质结合能力.研究强调其作为细菌生物纤维形成抑制剂的潜力及其对某些癌症细胞线的细胞毒性效应.在生理条件下的稳定性和选择性生物活性增强了其在药物开发中的适用性.进一步研究了它在调节氧化压力路径方面的作用.
- 英文名称1-(2,6-Dihydroxyphenyl)-9-(3,4-Dihydroxyphenyl)Nonan-1-One
- 中文名称马拉巴酮C
- IUPAC名称1-(2,6-dihydroxyphenyl)-9-(3,4-dihydroxyphenyl)nonan-1-one
- 其它别名Malabaricone C; 1-(2,6-Dihydroxyphenyl)-9-(3,4-Dihydroxyphenyl)Nonan-1-One; 1-(2,6-Dihydroxyphenyl)-9-(3,4-Dihydroxyphenyl)-1-Nonanone; 1-Nonanone, 1-(2,6-Dihydroxyphenyl)-9-(3,4-Dihydroxyphenyl)-; Lipid Metabolism,Inhibitor,Sphingomyelin Synthase,Sms 1,Diet,Obesity,Inhibit,Malabaricone C,Sms 2; Malabaricone C, 10 Mm In Dmso
- CAS编号63335-25-1
- MFCD编号:MFCD31557586
- FDA UNII编号:C9K53R3PRN
- 分子式:C21H26O5分子量:358.43
- 产品CID: 1614950
- 产品分类有机原料 → 有机氧化合物
物理性质
MSDS等安全信息
上下游产品
1-(2,6-Dihydroxyphenyl)-9-(3,4-Dimethoxyphenyl)Nonan-1-One 133839-80-21-(2-Benzyloxy-6-Hydroxyphenyl)-3-Hydroxy-9-(3,4-Dimethoxyphenyl)Nonan-1-One 133839-69-7
2,6-二羟基苯乙酮 2,6-Dihydroxyacetophenone 699-83-2
7-(3,4-Dimethoxyphenyl)Heptanal 133839-64-2
合成工艺路线路线简述
- 合成目标产物 Malabaricone C 主要起始原料 2',6'-Dihydroxyacetophenone
- (文献来源)合成步骤主要原料 2',6'-Dihydroxyacetophenone
📜(6-(Benzyloxy)Hexyl)Triphenylphosphonium Bromide置于palladium On Activated Charcoal 六甲基磷酰三胺,草酰氯,Potassium Tert-Butylate,氢气,三溴化硼,对甲苯磺酸,二甲基亚砜,三乙胺,Lithium Diisopropyl Amide体系中,用 乙醇,二氯甲烷,丙酮,苯 作为反应溶剂,-78.0~25.0 °C,392.24 Kpa 条件下,反应 36.17H,反应生成 马拉巴酮c
参考文献:Synthesis Of Malabaricones,Diarylnonanoids occurring In Myristicaceous Plants.
标题:Synthesis Of Malabaricones,Diarylnonanoids occurring In Myristicaceous Plants.
摘要:自然界存在的二芳基壬烷类化合物,马拉巴酮a,B,C,D和1-(2-羟基-6-甲氧基苯基)-9-(3,4-亚甲二氧苯基)-壬烷-1-酮,通过共同的中间体6-苄氧基己基三苯基膦溴化物,利用witting反应和交叉羟醛反应作为关键步骤合成.
DOI:10.1248/cpb.39.18
海关参考信息
- 2902600000-乙苯
2907210001-间苯二酚
2907221000-对苯二酚
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Total Syntheses Of Malabaricones B And C Via A Cross-Metathesis Strategy作者:Kshama Kundu,Sandip K. Nayak |发布日期:2017.6.23
摘要:Malabaricone C Displayed Various Interesting Biological Activities, Its Isolation Remains Tedious Due To Its Close Chemical Similarity To Malabaricones A, B, And D. Therefore, Development Of An Efficient Synthesis Route Has Become Essential To Cater To The Need Of Large Amounts Of Malabaricone C For Its Pharmacological Profiling. So Far There Is Only One Report Of The Synthesis Of Malabaricone C Through
合成参考文献
参考文献:10.3109/10715762.2015.1112005
摘要:Rathee JS, Patro BS, Brown L, Chattopadhyay S. Mechanism of the anti-hypertensive property of the naturally occurring phenolic, malabaricone C in DOCA-salt rats. Free Radic Res. 2016;50(1):111–21. doi: 10.3109/10715762.2015.1112005.
参考文献:10.1248/cpb.47.37
摘要:Hosoi S, Kiuchi F, Nakamura N, Imasho M, Ali MA, Sasaki Y, Tanaka E, Tsumamoto Y, Kondo K, Tsuda Y. Synthesis and nematocidal activity of diarylnonanoids related to malabaricones. Chem Pharm Bull (Tokyo). 1999 Jan;47(1):37–43. doi: 10.1248/cpb.47.37.
📝 需求与反馈
尽可能描述清楚需求与问题信息
