专利号:US-8338621-B2 优先权日:2005-12-21 标题:Process for the preparation of 2-oxo-1-pyrrolidine derivatives 发明人:SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY 权利人:SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY; UCB SA 摘要:The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I) n n n n n n n n n n Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.
专利号:US-8420055-B2 优先权日:2002-01-02 标 题:Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor 发明人:GAW DEBRA A; JOSEPHSON LEE 权利人:GAW DEBRA A; JOSEPHSON LEE; VISEN MEDICAL INC 摘要:Amine functionalized magnetic nanoparticle compositions and processes for synthesizing the same are described. The process consists of obtaining a carboxylated polymer in substantially pure form, which is used to prepare a substantially size homogeneous, polymer coated carboxyl, functionalized magnetic nanoparticle. The carboxyl groups are converted to reactive primary amino groups by the use of a water-soluble carbodiimide followed by reaction of a large excess of a diamine. The amine-terminated nanoparticles are then reacted with bifunctional crosslinking agents and with various biomolecules to make nanoparticles for in vitro assays, cell sorting applications and target specific MR contrast agents.
专利号:US-2003124194-A1 优先权日:2002-01-02 标 题:Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
专利号:US-2009068115-A1 优先权日:2002-01-02 标题 :Amine Functionalized Superparamagnetic Nanoparticles for the Synthesis of Bioconjugates and Uses Therefor
专利号:US-4288453-A 优先权日:1977-10-07 标 题 :Derivatives of arylalkanoic acids, compositions and use 发明人:VINCENT MICHEL; DUHAULT JACQUES; BOULLANGER MICHELLE; REMOND GEORGES 权利人:SCIENCE UNION & CIE 摘要:There are now described some novel alpha-[1-aryl-2,2,2-trifluoroethoxy (or-ethylthio)]alkanoic acids that are useful for reducing triglycerides and cholesterol levels in the blood of animals. The percentage reduction in test rats has been observed to be from 20 to 65 for triglycerides and from 15 to 50 for cholesterol. A representative compound of the invention is alpha-(2,2,2-trifluoro-1-phenyl-1-ethoxy)butyric acid. Most of the compounds have an LD 50 greater than 800 mg/kg, intraperitoneally, in male mice. n A method of use, compositions, and a process for synthesis are also described.
专利号:EP-1469989-A4 优先权日:2002-01-02 标题:AMINFUNCTIONALIZED SUPERPARAMAGNETIZED NANOTEHICLES FOR THE SYNTHESIS OF BIOKON JUGATES AND USES THEREOF
[参考文献]: T Ruppert, Et Al. Determination Of Urinary Trans,Trans-Muconic Acid By Gas Chromatography-Mass Spectrometry. J Chromatogr B Biomed Appl. 1995 Apr 7;666(1):71-6.
合成参考文献
摘要:Chemler, S. R.; Zabawa, T. P., Science of Synthesis, (2007) 20, 488. 摘要:Geffken, D.; Köllner, M. A., Science of Synthesis, (2009) 40, 1036.