专利号:US-4374979-A 优先权日:1981-04-27 标 题:Regiospecific synthesis of anthracyclinone compounds such as daunomycinone 发明人:MITSCHER LESTER A 权利人:UNIV KANSAS ENDOWMENT ASS 摘要:A regiospecific synthesis for anthracyclinones asymmetric is disclosed. The synthesis is based upon a regiospecific bromination of the C-7 position of the alpha -tetralone which after transposing the keto group to the beta -position and reaction with an organo-lithium compound is condensed with a phthalate ester.
专利号:EP-1749870-B1 优先权日:2005-08-04 标 题:Fluorescein-based compounds and their use for peptide synthesis 发明人:BALAKIREV MAXIM; BURCHAK OLGA 权利人:COMMISSARIAT ENERGIE ATOMIQUE 摘要:The present invention is related to new fluorescein derivatives, the method for producing such derivatives and their use for the synthesis of fluorogenic peptides and in particular protease substrates and peptide ligands.
专利号:US-6413957-B1 优先权日:1998-04-21 标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones 发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W 权利人:BRISTOL MYERS SUIBB PHARMA COM 摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
专利号:WO-9509170-A1 优先权日:1993-09-28 标 题:Chemical synthesis of rhodamine derivatives 发明人:CORRIE JOHN EDGAR THOMAS; CRAIK JAMES STANLEY 权利人:MEDICAL RES COUNCIL; CORRIE JOHN EDGAR THOMAS; CRAIK JAMES STANLEY 摘要:A method for preparing rhodamine derivatives of formulae (a) or (b) or a mixture of such compounds, where X is bromo, chloro- or iodoacetamido, maleimido, or amino. These compounds are the 5 and 6 (or 5' and 6') isomers of the amine, haloacetamide and maleimide derivatives of tetramethylrhodamine. The method enables for the first time the production of isomerically pure compounds on a relatively large scale. The products are fluorescent and are useful for the labelling of proteins.
专利号:US-4002664-A 优先权日:1973-06-09 标题 :Manufacture of dimethylaminobenzenecarboxylic acid esters 发明人:QUADBECK-SEEGER HANS-JUERGEN; HOCH HELMUT 权利人:BASF AG 摘要:Dimethylaminobenzenecarboxylic acid esters are produced by reaction of nitrobenzenecarboxylic acid esters with formaldehyde and hydrogen under pressure in the presence of a hydrogenation catalyst containing metals of atomic numbers 24 to 29 and of a weak acid, at temperatures from 35° to 150° C. The products are starting materials for the synthesis of dyes, especially of crystal violets, and of reactive dyes and pesticides.
专利号:US-6933405-B2 优先权日:2002-07-31 标题 :User- and eco-friendly hypervalent iodine reagent and method of synthesis 发明人:VINOD THOTTUMKARA K; THOTTUMKARA ARUN P 权利人:TRUSTEES OF WESTERN ILLINOIS U 摘要:The present invention is a user- and eco-friendly hypervalent iodine reagent (mIBX) capable of selectively oxidizing allylic and benzylic alcohols in water and other eco-friendly solvents and having generally the following structure: n n nAllylic and benzylic alcohols are cleanly oxidized to the corresponding carbonyl compounds in water or water-THF mixtures, or other mixtures, using a water-soluble o-iodoxybenzoic acid derivative of the present invention.
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