CAS: 58993-79-6; (2R)-1-(4-Methoxyphenyl)Propan-2-Amine

上下游产品

CAS号122-84-9 对甲氧基苯基丙酮 | CAS号3938-96-3 甲氧基乙酸乙酯 | CAS号64-13-1 para-Methoxyamp... | CAS号78-93-3 甲乙酮 | CAS号17354-63-1 1-(对甲氧基苯基)2-硝基丙烯 | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号37629-51-9 1-methoxy-4-[(E... | CAS号1351781-80-0 (R)-N-[2-(4'-me... | CAS号86073-42-9 Acetamide, N-[(...

📜(R)-N-[2-(4'-Methoxyphenyl)-1-Methylethyl]-2-Methoxyacetamide置于水,Potassium Hydroxide体系中,用70%的收率获得产物(R)-(-)-2-(4-甲氧基苯基)-1-甲基乙胺
参考文献:与苯丙胺结构相关的苯乙胺的酶促对映体拆分†
标题:与苯丙胺结构相关的苯乙胺的酶促对映体拆分†
摘要:几种苯乙胺的两种对映体,在结构上与 安非他命通过cal-B和cal-B的酶促动力学拆分,制备了高收率和优异的对映体纯度. 甲氧基乙酸乙酯作为酰基供体.在苯丙胺的4-羟基衍生物(化合物4I)的情况下,S对映异构体在所用的酶促条件下可能以动态动力学拆分(dkr)外消旋.
DOI:10.1039/c1Ob06251D

专利信息

专利号:US-4000197-A
优先权日:1973-07-23
标 题 :Asymmetric synthesis of phenylisopropylamines
发明人：BARFKNECHT CHARLES F; NICHOLS DAVID E
权利人:UNIV IOWA RES FOUND
摘要:The synthesis of enantiomers of a series of methoxy- and alkyl- substituted phenylisopropylamines is described. The synthesis comprises reducing the imines, formed by the reaction of appropriate phenylacetones with either (+)- or (-)-α-methylbenzylamine, by low-pressure reduction techniques, and subsequently subjecting the optically active N-(α-phenethyl)phenylisopropylamine derivative to hydrogenolysis. The hydrogenolysis products are characterized by enantiomeric purities in the range of 96 - 99%. Yields of products are approximately 60%.

专利号:US-7619116-B2
优先权日:2003-12-17
标 题:Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation
发明人：DAMBRIN VALERY; LENOIR JEAN-YVES; SCHNEIDER JEAN-MARIE; GUILLAMOT GERARD; FOLLET MICHEL; BECKER ABRAM
权利人:PRODUCTS CHIMIQUES AUXILIAIRES
摘要:A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.

专利号:US-7538246-B2
优先权日:2003-12-29
标 题:Synthesis of optically pure(r)-5-(2-amynopropyl)-2-methoxybenzenesulphonamide
发明人：MOHAR BARBARA
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to a new process for the preparation of optically pure(R)-5-(2-aminopropyl)-2-methoxybenzenesulphonamide, which is an intermediate in the synthesis of tamsulosin.

专利号:US-11717498-B2
优先权日:2013-12-31
标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms
发明人：POPP KARL; MECKLER HAROLD
权利人:Chemapotheca LLC; PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:US-7282606-B2
优先权日:2005-07-13
标题:Process for preparation of tamsulosin and its aralkylamine derivatives
发明人：JIH RU HWU; TSAY SHWU CHEN; MAGENDRAN BALAACHARY; CHAKRABORTY SUBHASISH K; DAS ASISH R; SHEU KUEN WANG; SHU CHUN MEI; LU CHIN KUN; CHANG WEI MIN
权利人:TAIWAN BIOTECH CO LTD
摘要:The present invention discloses a new process for the synthesis of tamsulosin and its aralkylamine derivatives, especially (R)-(−)-5-{2-[2-(2-alkoxyphenoxy) ethylamino]propyl}-2-alkoxybenzenesulfonamides having the following formula 1 (where R 1 and R 2 represent C 1 -C 4 alkyl groups) and their hydrochloride thereof, and other various pharmaceutical used salts. n n n n n n n n n n Tamsulosin hydrochloride (R 1 =Et, R 2 =Me, in its hydrochloride salt form) is an antagonist of α-A adrenoceptors in the prostate. Tamsulosin•HCl occurs as white crystals, which melt with decomposition at approximately 230° C. It is sparingly soluble in water and in methanol, slightly soluble in glacial acetic acid and in ethanol, and practically insoluble in ether.

专利号:EP-1734036-B1
优先权日:2005-06-14
标 题:Process for preparation of tamsulosin and its derivatives
发明人：JIH RU HWU; MAGENDRAN BALAACHARY; CHAKRABORTY SUBHASISH K; DAS ASISH R; TSAY SHWU CHEN; SHEU KUEN WANG; SHU CHUN MEI; LU CHIN KUN; CHANG WEI MIN
权利人:WELL BEING BIOCHEMICAL CORP; TAIWAN BIOTECH CO LTD
摘要:The present invention discloses a new process for the synthesis of tamsulosin derivatives of formula 1 (where R 1 and R 2 represent C 1 -C 4 alkyl groups) and their hydrochlorides and other pharmaceutically acceptable salts, comprising reacting the hydrochloride of sulphonamide 2 (where R represents C 1 -C 4 alkyl) with the ether compound 21 (where R' represents C 1 -C 4 alkyl and R' represents MeC 6 H 4 SO 2 or MeSO 2 ).