CAS: 5696-06-0; 5-Ethyl-1-Methyl-5-Phenylimidazolidine-2,4-Dione

📜在 甲烷磺酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 24.0H,以132 Mg的收率获得产物美替妥英
参考文献:Palladium Catalyzed C-Arylation Of Amino Acid Derived Hydantoins
标题:Palladium Catalyzed C-Arylation Of Amino Acid Derived Hydantoins
摘要:Palladium(II) Trifluoroacetate (5 Mol %) Catalyzes The C-Arylation Of N,N-Disubstituted Hydantoins By Aryl Iodides In Good Yield. The Reaction Proceeds Through Base-Promoted Enolization Of The Amino Acid Derived Hydantoins,And The Resulting 5,5-Disubstituted Hydantoins May Be Deprotected At One Or Both N Atoms To Yield Biologically Active Structures Or Alternatively Hydrolyzed To The Parent A-Aryl A-Amino Acids. The Reaction Is Successful With A Variety Of Parent Amino Acids And A Range Of Electron-Rich And Electron-Poor Aryl Iodides.
DOI:10.1021/acs.Orglett.5B01803

专利信息

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:CA-2555219-A1
优先权日:2004-02-03
标 题 :Synthesis of cyanoimino-benzoimidazoles

专利号:WO-2005075459-A1
优先权日:2004-02-03
标题:Synthesis of cyanoimino-benzoimidazoles

专利号:JP-2007520493-A
优先权日:2004-02-03
标 题 :Synthesis of cyanoiminobenzimidazole

专利号:EP-1711484-A4
优先权日:2004-02-03
标题:SYNTHESIS OF CYANOIMINO-BENZOIMIDAZOLES

专利号:EP-1711484-A1
优先权日:2004-02-03
标 题:Synthesis of cyanoimino-benzoimidazoles