CAS: 5394-18-3; 2-(4-Bromobutyl)Isoindoline-1,3-Dione

上下游产品

CAS号110-52-1 1,4-二溴丁烷 | CAS号1074-82-4 邻苯二甲酰亚胺钾盐 | CAS号24697-70-9 2-(4-羟基丁基)异二氢吲哚... | CAS号85-44-9 苯酐 | CAS号40898-95-1 1-(-)-2-amino-1... | CAS号101732-28-9 2-[4-(4-nitroph... | CAS号14122-46-4 4-(1,3-dioxoiso... | CAS号14064-34-7 4-aminobutane-1... | CAS号21100-03-8 4-aminobutane-1... | CAS号21103-33-3 4-4 -(2-甲氧基-苯基)-... | CAS号19532-98-0 N1,N2-二甲基邻苯二甲酰胺 | CAS号1875-48-5 N-氨基邻苯二甲酰亚胺 | CAS号88-96-0 邻苯二甲酰胺 | CAS号74247-30-6 4-哌啶-1-丁基-1-胺 | CAS号65273-47-4 (4-邻苯二甲酰亚胺丁基)三苯基溴化膦

5-(1,3-二氧-1,3-二氢异吲哚-2-基)-戊酸置于碘苯二乙酸,Potassium Bromide体系中,用 二氯甲烷 作为反应溶剂,以71%的收率获得产物n-(4-溴丁基)邻苯二甲酰亚胺
参考文献:高价碘试剂对立体受阻羧酸的脱羧溴化反应
标题:高价碘试剂对立体受阻羧酸的脱羧溴化反应
摘要:立体受阻的三维(3D)烷基卤化物是各种反应的有希望的前体;但是,它们难以通过常规反应合成.我们提供了使用市售的(diacetoxyiodo)苯和溴化钾(自然界中最稳定和最便宜的溴源之一)对位阻3D脂肪族羧酸进行脱羧溴化的高效实用方法.本方法的特点是不含金属/ Br 2无体系,温和的反应条件,在室温下空气中一锅操作,广泛的官能团相容性和克级合成能力.这种高效的反应可以以高收率或高收率干净地将各种羧酸(高度紧张/天然存在/与药物相关的支架的最便宜和最容易获得的来源)转化为相应的烷基溴化物.
DOI:10.1021/acs.Oprd.0C00130

专利信息

专利号:US-2022098170-A1
优先权日:2019-01-16
标 题 :Process for the synthesis of gepirone
发明人：COLOMBANO GIAMPIERO; BARBERO MAURO; GIOVENZANA GIOVANNI BATTISTA; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of gepirone of formula (I) from 8-(pyrimidin-2-yl)-5,8-diazaspiro[4,5]decan-5-ium bromide. The process according to the invention is economically efficient and easily industrially scalable.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:US-9458100-B2
优先权日:2012-10-12
标 题:Synthesis and growth regulatory activity of a prototype member of a new family of aminothiol radioprotectors
发明人：FAHL WILLIAM E
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The synthesis, growth inhibition and radioprotective activity of the PrC-210 aminothiol, 3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol, and its polyamine and thiolated polyamine progenitors are reported. All of the molecules significantly inhibited growth of cultured normal human fibroblasts. The combination of an ROS-scavenging thiol group and a positively charged alkyl-amine backbone provided the most radioprotective aminothiol molecule.

专利号:WO-2017135901-A1
优先权日:2016-02-05
标题 :Heterocyclic compounds, methods of synthesis and uses thereof
发明人：CHUA BOON TIN; KERI GYORGY; ORFI LASZLO; Németh Gábor; WÃ?CZEK FRIGYES; Varga Zoltán; MARKO PETER
权利人:AGENCY SCIENCE TECH & RES; VICHEM CHEMIE RES LTD
摘要:The present invention relates to 3-quinolinecarbonitrile compounds of formula (I) disclosed herein, methods for their synthesis, and uses thereof. Advantageously, the disclosed heterocyclic compounds may demonstrate enhanced efficacy in antitumor properties. Hence, the present disclosure also relates to the use of the disclosed 3-quinolinecarbonitrile compounds or pharmaceutical compositions thereof in cancer treatment.

专利号:US-6956131-B2
优先权日:2000-04-13
标 题 :2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
发明人：PITZELE BARNETT S; SIKORSKI JAMES A; WEBBER RONALD KEITH
权利人:PHARMACIA CORP
摘要:The present invention is directed to a compound of formula I: n n nor a pharmaceutically acceptable salt thereof, wherein:n R 2 is selected from the group consisting of H and methyl; and R 2 is selected from the group consisting of H and methyl.n nThe compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.

专利号:US-7320993-B1
优先权日:1997-12-17
标题 :Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
发明人：BIEDERMANN ELFI; HASMANN MAX; LOESER ROLAND; RATTEL BENNO; REITER FRIEDEMANN; SCHEIN BARBARA; SEIBEL KLAUS; VOGT KLAUS; WOSIKOWSKI KATJA; SCHEMAINDA ISABEL
权利人:ASTELLAS DEUTSCHLAND GMBH
摘要:The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.