CAS: 5250-39-5; Flucloxacillin

上下游产品

6-Aminopenicillanic Acid 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chlorideFlucloxacillin sodium 5-Hydroxymethylflucloxacillin carbon dioxide 5,5-dimethyl-thiazolidine-2,4-dicarboxlic acid

📜6-氨基青霉烷酸,3-(2-氯-6-氟苯基)-5-甲基异唑-4-羰基氯置于sodium Carbonate体系中,用 水 作为反应溶剂,化学反应 5.0H,反应生成 氟氯西林
参考文献:一种氟氯西林钠一水合物的合成方法
标题:一种氟氯西林钠一水合物的合成方法
摘要:本发明公开了一种氟氯西林钠一水合物的合成方法,属于药物合成技术领域,其步骤为:将6‑apa成盐,然后加入3‑(2‑氯‑6‑氟苯基)‑5‑甲基异恶唑‑4‑甲酰氯或其等价物进行酰化反应,然后滴加酸,调节ph得到氟氯西林酸水溶液;再用有机溶剂萃取,有机相用饱和食盐水洗涤干燥,过滤,得到氟氯西林酸溶液,再加入异辛酸钠溶液所得的氟氯西林酸溶液中,析出白色固体,控温析晶,得到产品;本发明不分离中间体氟氯西林酸,所得氟氯西林酸经有机溶剂萃取后,直接与异辛酸钠成盐,减少了分离步骤及操作工艺,同时也减少了有机溶剂的使用量及次数,相对于专利文献cn102964356A,大大减少了有机溶剂的排放量,降低了生产成本20%以上,显著地提高了经济效益和环保价值.

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:US-10927135-B2
优先权日:2017-08-03
标 题:Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates
发明人：KANG JUN YONG; HUANG HAI
权利人:THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE
摘要:Provided herein are phosphates, thiophosphates, phosphonates, and phosphinates, methods of making same, and methods of using these compounds and methods for the generation of pharmaceutically relevant phosphate, phosphonate, and phosphinate analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-10899773-B2
优先权日:2014-12-19
标 题 :Total synthesis of trioxacarcin DC-45-A2 and preparation of trioxacarcin analogs
发明人：NICOLAOU KYRIACOS C; CAI QUAN
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of trioxacarin analogs of the formula (I) wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.

专利号:US-2016185745-A1
优先权日:2013-08-07
标题:Analogs of vinaxanthone and xanthofulvin, methods of synthesis, and methods of treatments thereof
发明人：SIEGEL DIONICIO; CHIN MATTHEW; ELIASEN ANDERS; AXELROD ABRAM
权利人:UNIV TEXAS
摘要:The present invention relates generally to methods of synthesis of vinaxanthone and xanthofulvin, novel analogs, and methods of use thereof.

专利号:US-6777554-B2
优先权日:2001-02-05
标题 :Preparation of N-methylparoxetine and related intermediate compounds
发明人：FINKELSTEIN NINA
权利人:TEVA PHARMA
摘要:The present invention provides a process for preparing N-methylparoxetine, an intermediate in the synthesis of paroxetine, by reacting sesamol-tetrabutylammonium salt with CIPMA. The present invention is not limited to the synthesis of N-methylparoxetine, but also includes other similar compounds.