CAS: 4985-92-6; 5-Methylpicolinaldehyde

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1620-77-5 4434-13-3 29681-38-7

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CAS号3510-66-5 2-溴-5-甲基吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号3430-13-5 5-溴-2-甲基吡啶 | CAS号661458-29-3 5-METHYL-2-PYRI... | CAS号55876-82-9 5-甲基吡啶-2-羧酸乙酯5-... | CAS号1620-77-5 2-氰基-5-甲基吡啶 | CAS号22940-71-2 5-甲基-吡啶-2-基)甲醇 | CAS号589-93-5 2,5-二甲基吡啶 | CAS号772-71-4 2-acetoxymethyl... | CAS号4434-13-3 5-甲基-2-甲酸吡啶 | CAS号99584-04-0 Hydroxy(5-methy... | CAS号3883-39-4 5-甲基-2-烯基吡啶

2,5-二甲基吡啶置于manganese(Iv) Oxide,2,2,2-三氟苯乙酮,双氧水,Potassium Carbonate,乙腈,三氟乙酸酐体系中,用 二氯甲烷,水,1,2-二氯乙烷,叔丁醇 作为反应溶剂,化学反应 80.0H,反应生成 5-甲基吡啶-2-甲醛
参考文献:Methyl Scanning And Revised Binding Mode Of 2-Pralidoxime,An Antidote For Nerve Agent Poisoning
标题:Methyl Scanning And Revised Binding Mode Of 2-Pralidoxime,An Antidote For Nerve Agent Poisoning
摘要:Organophosphorus Nerve Agents (Opnas) Inhibit Acetylcholinesterase (Ache) And,Despite The Chemical Weapons Convention Arms Control Treaty,Continue To Represent A Threat To Both Military Personnel And Civilians. 2-Pralidoxime (2-Pam) Is Currently The Only Therapeutic Countermeasure Approved By The United States Food And Drug Administration For Treating Opna Poisoning. However,2-Pam Is Not Centrally Active Due To Its Hydrophilicity And Resulting Poor Blood-Brain Barrier Permeability; Hence,These Deficiencies Warrant The Development Of More Hydrophobic Analogs. Specifically,Gaps Exist In Previously Published Structure Activity Relationship (Sar) Studies For 2-Pam,Thereby Making It Difficult To Rationally Design Novel Analogs That Are Concomitantly More Permeable And More Efficacious. In This Study,We Methodically Performed A Methyl Scan On The Core Pyridinium Of 2-Pam To Identify Ring Positions That Could Tolerate Both Additional Steric Bulk And Hydrophobicity. Subsequently,Sar-Guided Molecular Docking Was Used To Rationalize Hydropathically Feasible Binding Modes For 2-Pam And The Reported Derivatives. Overall,The Data Presented Herein Provide New Insights That May Facilitate The Rational Design Of More Efficacious 2-Pam Analogs.
DOI:10.1021/acsmedchemlett.9B00586

专利信息

专利号:US-2008064842-A1
优先权日:2004-09-23
标题 :In-Situ Chain Extended Rtv-Curing Polyether
发明人：JACOBINE ANTHONY F; NAKOS STEVEN T
权利人:JACOBINE ANTHONY F; NAKOS STEVEN T
摘要:The present invention provides moisture-curable polymeric compositions, overcoming disadvantages normally associated with moisture-curable polymeric compositions, a process for their preparation, and methods of use thereof. The process included in the present invention ensures full end-capping. Furthermore, the present invention makes use of diisocyanates to chain-extend polyether polyols to a desired length. This allows the process of the present invention to accommodate a wide range of polyether polyols in the synthesis of the compounds of the invention. Additionally, the process of the present invention reduces the level of unreacted isocyanate to an acceptable level of approximately 0.1 wt %.

专利号:US-9670230-B2
优先权日:2012-11-29
标题 :Heteroaryl compounds and methods of use thereof
发明人：CAMPBELL JOHN EMMERSON; JONES PHILIP
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

专利号:US-4681891-A
优先权日:1984-11-27
标 题 :Dihydro-2,6-dimethyl pyridines, formulations and method of use for treating angina pectoris, high blood pressure or disturbances of cerebral or peripheral blood flow
发明人：SCHOENAFINGER KARL; BOHN HELMUT; MARTORANA PIERO; NITZ ROLF-EBERHARD
权利人:CASSELLA FARBWERKE MAINKUR AG
摘要:1,4-dihydropyridines of the formula I (I) wherein R1 denotes optionally substituted phenyl, pyridyl or thienyl, R2 denotes optionally substituted oxadiazolyl, thiadiazolyl or thiazolyl and R3 denotes hydrogen or -COOH, their preparation by a modified Hantzsch synthesis and their use as a calcium-agonist in pharmacy.

专利号:CN-113603687-A
优先权日:2021-08-02
标 题:A new method for the synthesis of cyano-substituted imidazo[1,5-a]pyridines

专利号:US-5084458-A
优先权日:1987-05-14
标 题 :Substituted 2-acylpyridine-β-(N)-hetaryl-hydrazones and medicaments containing the same
发明人：SCHAPER KLAUS-JUERGEN; SEYDEL JOACHIM K
权利人:SCHAPER KLAUS JUERGEN; SEYDEL JOACHIM K
摘要:PCT No. PCT/DE88/00289 Sec. 371 Date Mar. 7, 1989 Sec. 102(e) Date Mar. 7, 1989 PCT Filed May 14, 1988 PCT Pub. No. WO88/08842 PCT Pub. Date Nov. 17, 1988.Substituted 2-acylpyridine- alpha -(N)-hetarylhydrazones are described, which are suitable as active substances for the treatment of antimicrobial and in particular antimycobacterial diseases, as well as active substances for the treatment of malaria or malignant tumours. The compounds have a marked synergistic activity combined with inhibitors of folate synthase, dihydrofolic acid reductase, DNA-synthesis and RNA-synthesis.

专利号:CN-102875452-A
优先权日:2012-10-22
标题:A kind of chemical synthesis method of 2-(2'-pyridyl) cyclopropanecarboxylic acid derivative