CAS: 458-45-7; 3-(3-Fluorophenyl)Propionic Acid

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CAS号20595-30-6 反式-3-氟肉桂酸 | CAS号456-48-4 3-氟苯甲醛 | CAS号124-38-9 二氧化碳 | CAS号25017-13-4 3-氟溴乙基苯 | CAS号52059-53-7 2-(3-氟苯基)乙醇 | CAS号331-25-9 3-氟苯乙酸 | CAS号456-42-8 间氟氯苄 | CAS号252938-21-9 methyl 3-(3-flu... | CAS号59223-73-3 Propanedioic ac... | CAS号404-70-6 3-氟苯乙胺 | CAS号245070-85-3 3-(3-氟-苯基)-丙醛 | CAS号700-84-5 5-氟-1-茚酮 | CAS号156868-83-6 3-(3-Fluorophen... | CAS号214045-84-8 6-氟-3,4-二氢-1(2H...

3-氟苯乙醇置于四溴化碳,Magnesium,三苯基膦体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应生成 3-(3-氟苯基)丙酸
参考文献:The Effect Of Vinyl Esters On The Enantioselectivity Of The Lipase-Catalysed Transesterification Of Alcohols
标题:The Effect Of Vinyl Esters On The Enantioselectivity Of The Lipase-Catalysed Transesterification Of Alcohols
摘要:The Enantioselectivity Of The Lipase From Pseudomonas Cepacia (Pcl) In The Transesterification Of 2-Phenyl-1-Propanol I Was Studied Using A Series Of Vinyl 3-Arylpropanoates As Acyl Donors. The Most Enantioselective Transesterification Reaction Of The Alcohol Was Attained By Using Vinyl 3-(P-Iodophenyl)-Or 3-(P-Trifluoromethylphenyl)Propanoates,With Enantiomer Ratios,E,Of 116 And 138,Respectively. Vinyl 3-Phenylpropanoate Was Also Effective For The Resolution Of 1 Mediated By Lipases From P. Fluorescens And Porcine Pancreas And For The Pcl-Catalysed Transesterification Of Several 2-Phenyl-1-Alkanols. The Enantiomeric Resolution Of 1 Was Practically Carried Out By The First Enantioselective Transesterification Using Pcl And Vinyl 3-(P-Iodophenyl)Propanoate To Afford (R)-1 And Then The Enantioselective Hydrolysis Of The Resultant Ester To Afford (S)-1. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0957-4166(01)00083-0

专利信息

专利号:WO-2015131100-A1
优先权日:2014-02-28
标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

专利号:US-12304894-B2
优先权日:2019-04-17
标题 :Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1)
发明人：FARDELLA BELLO CARLOS ENRIQUE; LAGOS ARÉVALO CARLOS FERNANDO; VECCHIOLA CÃ?RDENAS ANDREA PAOLA; ALLENDE SANZANA FIDEL ALEJANDRO; DIETHELM VARELA BENJAMIN MANUEL; RECABARREN GAJARDO GONZALO IVAN; GONZÃ?LEZ CISTERNA PABLO MARCELO
权利人:UNIV PONTIFICIA CATOLICA CHILE
摘要:The present invention relates to compounds derived from adamantyl oxadiazoles and the pharmaceutically acceptable solvates, hydrates and salts of same. These compounds are suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1), as well as in the production of a drug for treating conditions and diseases such as high blood pressure, obesity, dyslipidaemia, type 2 diabetes, insulin resistance, glaucoma, metabolic syndrome, cognitive disorders, osteoporosis, immune disorders, depression and other conditions. Also provided is a pharmaceutical composition comprising the compounds and a method for preparing said composition.

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:EP-3305900-B1
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:WO-2020210922-A1
优先权日:2019-04-17
标题 :Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-hsd1)

专利号:CA-3136838-A1
优先权日:2019-04-17
标 题:Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11.beta.-hsd1)