CAS: 3453-33-6; 6-Methoxy-2-Naphthaldehyde

相似化合物

2471-70-7 2471-70-7 60201-22-1

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CAS号5111-65-9 2-溴-6-甲氧基萘 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号201230-82-2 carbon monoxide | CAS号67886-70-8 6-甲氧基-2-萘甲腈 | CAS号26386-94-7 2-Methoxy-6-met... | CAS号60201-22-1 6-甲氧基-2-萘甲醇 | CAS号581-42-0 2,6-二甲基萘 | CAS号15231-91-1 6-溴-2-萘酚 | CAS号42924-53-8 萘丁美酮 | CAS号26386-94-7 2-Methoxy-6-met... | CAS号78119-82-1 6-羟基-2-萘甲醛 | CAS号53526-25-3 6-甲氧基-2-萘庚酮 | CAS号63444-51-9 6-甲氧基-2-萘乙烯 | CAS号71056-96-7 2-(6-甲氧基萘-2-基)乙腈 | CAS号23981-80-8 2-(6-甲氧基-2-萘基)丙酸 | CAS号23981-47-7 6-甲基萘乙酸 | CAS号21388-17-0 2-乙基-6-甲氧基萘 | CAS号2471-70-7 6-甲氧基-2-萘甲酸

(6-甲氧基萘-2-基)甲醇置于2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 水,溶剂黄146 作为反应溶剂,化学反应 4.0H,以95%的收率获得产物6-甲氧基-2-萘甲醛
参考文献:电有机反应.第56部分:2-甲基-和2-苄基萘的阳极氧化:影响竞争途径的因素
标题:电有机反应.第56部分:2-甲基-和2-苄基萘的阳极氧化:影响竞争途径的因素
摘要:系统地研究了在萘核的6位和苄基侧链的4-苯基位取代的2-甲基和2-苄基萘在亲核介质中的阳极氧化作用,以确定有利于环境的因素侧链取代.循环伏安法证实6-取代对萘核的氧化电位有深远的影响,13 C化学位移表明在苄基碳上有极性作用.然而,在任何尝试的条件下,几乎都没有观测到侧链阳极氧化.富电子底物的自由基阳离子优先二聚,并且在6位上具有强吸电子取代基(etoso 2)促进核替代.相反,在含水乙酸中用ddq氧化可对富含电子的底物进行有效的侧链氧化,这与氢化物转移(可能在分子内通过电荷转移络合物)转移一致.
DOI:10.1016/s0040-4020(02)00495-7

专利信息

专利号:WO-2020230156-A1
优先权日:2019-05-10
标题 :A catalyst for one pot synthesis of nabumetone and process of preparation thereof
发明人：YADAV GANAPATI DADASAHEB; PISAL DEVENDRA SHRIRAM
权利人:YADAV GANAPATI DADASAHEB
摘要:The present invention relates to novel heterogeneous catalyst composition for selective synthesis of Nabumetone in one pot process and process to prepare the catalyst. The present invention provides a novel catalyst comprises of Lanthanum, Magnesium, and Nickel particles doped on specific type of silica support, preferably that the support is in amorphous nature. The catalyst is having bifunctional condensation and hydrogenation properties for one pot synthesis of Nabumetone comprising of: Nickel and Lanthanum-magnesium mixed oxide on support of mesoporous silica; Wherein 25 to 30 % w/w of Lanthanum-magnesium mixed oxide are entrapped in pores and surface of support is coated with 3 to 5% w/w Nickel with the result that it prevent the leaching of Lanthanum-magnesium mixed oxide in reaction medium and provides reusability of catalyst.

专利号:US-RE37813-E
优先权日:1996-02-21
标题 :Process for the synthesis of nabumetone
发明人：CANNATA VINCENZO; BERTONI AMILCARE; BIANCHI STEFANO
权利人:HONEYWELL INT INC
摘要:New process for the synthesis of the antiinflammatory drug known as nabumetone that consists in reacting 2-acetyl-5-bromo-6-methoxynaphthalene with an alkyl acetate in presence of an alkaline alcoholate to get 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one that by catalytic hydrogenation in a polar solvent and in presence of a base gives 4-(6-methoxy-2-naphthyl)butan-2-one known as nabumetone.

专利号:US-5763681-A
优先权日:1989-09-06
标 题 :Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
发明人：EDWARDS BROOKS; JUO RHOU-RONG
权利人:TROPIX INC
摘要:A novel synthesis of compound having the formula: ##STR1## wherein T is a stabilizing spiro-linked polycycloalkylidene group, R 3 is a C 1 -C 20 alkyl, aralkyl or heteroatom containing group, Y is an aromatic fluorescent chromophore, and Z is a cleavable group which, when cleaved, induces decomposition of the dioxetane ring and emission of optically detectable light, is disclosed. A tertiary phosphorous acid alkyl ester of the formula: n n (R.sup.1 O).sub.3 P n n wherein R 1 is a lower alkyl group, is reacted with an aryl dialkyl acetal produced by reacting a corresponding aryl aldehyde with an alcohol of the formula: n n R.sup.3 OH n n wherein R 3 is as defined above, to produce a 1-alkoxy-1-aryl-methane phosphonate ester of the formula: ##STR2## reacting the phosphonate with base to produce a phosphonate-stabilized carbanion, reacting the carbanion with a ketone of the formula: ##STR3## wherein T is as defined above, to produce an enol ether of the formula: ##STR4## then oxygenating the double bond in the enol ether to give the corresponding 1,2-dioxetane compound.

专利号:US-6683205-B2
优先权日:2001-02-15
标 题 :Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs
发明人：HOSSAIN M MAHMUN
权利人:WISYS TECHNOLOGY FOUND INC
摘要:A method of producing a compound of the formula: n and its pharmaceutically acceptable salts, wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic group; comprising: n (1) reacting a compound of the formula: n wherein Ar is as described above, with N 2 CHCOOR, wherein R is alkyl, in the presence of a catalytic amount of a Bronsted acid or Lewis acid to form a compound of the formula: n wherein Ar and R are as described above; and n (2) reacting the compound of formula (II) with a reducing agent in the presence of an alkyl amine to form a compound of the formula: n wherein Ar and R are as described above.

专利号:US-7323483-B2
优先权日:2005-01-27
标题:Processes and compounds for the preparation of substituted naphthylindole derivatives
发明人：DRAGAN VLADIMIR A; POTOSKI JOHN RICHARD; MCMAHON WAYNE G; HELOM JEAN LOUISE; SHI XINXU
权利人:WYETH CORP
摘要:The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.

专利号:US-9994572-B2
优先权日:2015-09-04
标题 :Therapeutic compounds for pain and synthesis thereof
发明人：DECORTE BART; RUSSCHER JACOB CORNELIS; MONNEE MENNO CORNELIS FRANCISCUS
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention provides compounds of Formula 1: n nand stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.