CAS: 22661-76-3; Amoproxan
该化合物是其中度溶液在水和有机溶剂中的溶液,有利于其在各种配方中使用.其药学特征表明,在治疗焦虑和抑郁等条件下,有可能应用该物质,尽管需要进一步研究,以充分理解其功效和安全性.与许多具有药效作用的物质一样,其具体特征,包括其行动机制,副作用和与其他药物的相互作用,对于治疗用途至关重要,需要在临床环境中仔细考虑.
- 英文名称Amoproxan
- 中文名称克冠吗啉
- IUPAC名称alpha-(Isopentyloxymethyl)-4-morpholineethanol 3,4,5-trimethoxybenzoate (ester)
- 其它别名Benzoic acid,3,4,5-trimethoxy-, 1-[(isopentyloxy)methyl]-2-morpholinoethyl ester (8CI); 4-Morpholineethanol, a-[(isopentyloxy)methyl]-, 3,4,5-trimethoxybenzoate (ester) (8CI); 4-[3-(Isoamyloxy)-2-(3,4,5-trimethoxybenzoyloxy)propyl]tetrahydro-1,4-oxazine; Amoproxan
- CAS编号22661-76-3
- MFCD编号:MFCD00864741
- FDA UNII编号:27RL57FCYM
- 分子式:C22H35NO7分子量:425.52
- 产品CID: 1165142
- 产品分类有机原料 → 苯类化合物 → 苯取代衍生物
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2905130000-正丁醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications
专利号:AU-2007308022-B2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Degos R, Civatte J, Belaïch S, Schnitzler L, Larrègue M, Sedel D. [Dermatitis of uncovered parts in 6 patients taking amoproxan (Mederel)]. Bull Soc Fr Dermatol Syphiligr. 1970;77(4):497-9. French. French. French. French. French.
合成参考文献
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
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