CAS: 20426-12-4; 3-(4-Hydroxyphenyl)-1-Phenylprop-2-En-1-One

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CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号98-86-2 苯乙酮 | CAS号22252-15-9 4-甲氧基查耳酮 | CAS号70-11-1 2-溴苯乙酮 | CAS号13735-81-4 1-苯基-1-三甲基硅氧乙烯 | CAS号614-47-1 反-查耳酮 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号98-86-2 苯乙酮 | CAS号17791-25-2 3-(4-hydroxyphe... | CAS号74629-69-9 4-(4-phenyl-2,3...

4-Methoxymethoxy-Benzaldehyde置于盐酸,水,Sodium Hydroxide体系中,用 乙醇 用作溶剂,化学反应 48.0H,反应生成2-羟基查耳酮
参考文献:Design,Synthesis And Bioactivity Of Chalcones And Its Analogues
标题:Design,Synthesis And Bioactivity Of Chalcones And Its Analogues
摘要:The Vernohia Anthelmintica L'S Extract Is One Of The Most Popular Uygur Medicines Used For Vitiligo. It Is Believed That The Chalcone Compounds Of The Plant Play An Important Role In The Treatment Since They May Activate Tyrosinase And Improve Melanin Production. In This Study,Twenty-One Chalcones And Nine Analogues Were Synthesized In View Of Three Different Components Of Chalcone (A,B Ring And A,Beta-Unsaturated Carbonyl). After Biological Evaluation Of Their Activity On Tyrosinase In Cell-Free Systems,The Result Showed That Most Compounds (Except Polyhydroxy Chalcones) Possess Activator Effect On The Tyrosinase,Especially For 13A-15A,20A And 1 B,Which Bearing A Comparable Activity To The Positive Control 8-Mop. Sar Of These Tyrosinase Activator Was Summed Up For The First Time As Well. Finally,Compound 13A Was Found To Increase Melanin Contents And Tyrosinase Activity 1.75 And 1.3 Fold,Respectively,Compared With That Of Untreated Murine B16 Cells At The Concentration Of 40 Mu G/ml (C) 2017 Chinese Chemical Society And Institute Of Materia Medica,Chinese Academy Of Medical Sciences. Published By Elsevier B.V. All Rights Reserved.
Doi:10.1016/j.Cclet.2017.03.018

专利信息

专利号:US-7851654-B2
优先权日:2006-04-03
标题 :Chalcone derivatives, pharmaceutically acceptable salt, method for preparation and uses thereof
发明人：PARK KI HUN; KIM JIN HYO; SEO WOO DUCK; RYU YOUNG BAE; RYU HYUNG WON; LEE WOO SONG; GAL SANG WAN
权利人:IND ACADEMIC COOP
摘要:Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.

专利号:CN-110041198-B
优先权日:2019-04-03
标题:Synthesis method of chalcone-containing aryloxycarboxylate compound and application of the compound in pesticide