CAS: 172895-15-7; 1-[(3,4-Dimethoxyphenyl)Methyl]-6-Methyl-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole

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(Z)-4-(3,4-dimethoxybenzylidene)-2-methyl-5(4H)-oxazolone 5-methyltryptamine hydr°Chloride 3,4-dimethoxy-benzaldehyde

📜(Z)-4-(3,4-Dimethoxybenzylidene)-2-Methyl-5(4H)-Oxazolone,5-甲基色胺盐酸盐置于盐酸体系中,化学反应生成1-(3,4-二甲氧基苄基)-6-甲基-2,3,4,9-四氢-1H-吡啶并[3,4-B]吲哚盐酸盐
参考文献:Potent,Selective Tetrahydro-β-Carboline Antagonists Of The Serotonin 2B (5Ht2B) Contractile Receptor In The Rat Stomach Fundus
标题:Potent,Selective Tetrahydro-β-Carboline Antagonists Of The Serotonin 2B (5Ht2B) Contractile Receptor In The Rat Stomach Fundus
摘要:A Series Of Potent,Selective 5Ht(2B) Receptor Antagonists Has Been Identified Based Upon Yohimbine,With Sar Studies Resulting In A 1000-Fold Increase In 5Ht(2B) Receptor Affinity Relative To The Starting Structure (-Log K(B)S > 10.0 Have Been Obtained). These High-Affinity Tetrahydro-Beta-Carboline Antagonists Are Able To Discriminate Among The 5Ht(2) Family Of Serotonin Receptors,With Members Of The Series Showing Selectivities Of More Than 100-Fold Versus Both The 5Ht(2A) And 5Ht(2C) Receptors Based Upon Radioligand Binding And Functional Assays. As The First Compounds Reported With Such Selectivity And Enhanced Receptor Affinity,These Tetrahydro-Beta-Carboline Antagonists Are Useful Tools For Elucidating The Role Of Serotonin Acting At The 5Ht(2B) Receptor In Normal And Disease Physiology.
Doi:10.1021/jm960062T