CAS: 16427-44-4; 2-Methoxyethyl Methanesulfonate

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34604-52-9 130955-37-2 60696-83-5

上下游产品

CAS号109-86-4 乙二醇甲醚 | CAS号124-63-0 甲基磺酰氯 | CAS号616-47-7 N-甲基咪唑 | CAS号256224-02-9 2-氨基-3-o-(2-甲氧基... | CAS号847647-19-2 2-Amino-2’,3’-b... | CAS号256224-13-2 2-氨基-2-o-(2-甲氧基... | CAS号109-86-4 乙二醇甲醚 | CAS号1062491-29-5 ((2R,3R,4R,5R)-... | CAS号168427-74-5 2'-O-(2-甲氧乙基)腺苷 | CAS号1062491-27-3 (2R,3R,4R,5R)-2... | CAS号183322-16-9 3,4-二(2-甲氧基乙氧基)苯甲酸乙酯 | CAS号649724-44-7 2-bromo-9,9-bis...

📜乙二醇甲醚,甲基磺酰氯置于三乙胺体系中,用 二氯甲烷 用作溶剂,以97%的收率获得甲磺酸2-甲氧基乙酯
参考文献:用于智能离子液体的两性离子溶液,可避免细胞毒性
标题:用于智能离子液体的两性离子溶液,可避免细胞毒性
摘要:通过连接离子液体 (Il) 的阳离子和阴离子基序,两性离子液体 (Zil) 在人胃和结肠细胞中的细胞毒性比结构相关的 Il 至少低 146-2740 和 112-1550 倍.计算机模拟表明,与 Il 相比,Zil 分子几乎无法穿透细胞膜.这些发现揭示了 Zil 逃避细胞毒性的新机制,为下一代可持续 Zil 建立了基于结构的设计原则.
Doi:10.1016/j.Jhazmat.2023.131430

专利信息

专利号:US-8329958-B2
优先权日:2004-07-02
标 题:Combinatorial synthesis of PEG oligomer libraries
发明人：RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N
权利人:RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N; BIOCON LTD
摘要:A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.

专利号:US-2010184989-A1
优先权日:2007-03-12
标 题 :De Novo Synthesis of Conjugates
发明人：RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J
权利人:NEKTAR THERAPEUTICS
摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

专利号:US-2024299311-A1
优先权日:2022-04-05
标题 :Ionizable cationic lipids and lipid nanoparticles
发明人：KARMALI PRIYA PRAKASH; TANIS STEVEN
权利人:KARMALI PRIYA PRAKASH; TANIS STEVEN; CAPSTAN THERAPEUTICS INC
摘要:Ionizable cationic lipids, methods for synthesizing them, as well as intermediates useful in synthesis of these lipids and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for the delivery of nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNP comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNP (tLNP), that is a LNP in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNP to a desired tissue or cell type.

专利号:CN-114835765-B
优先权日:2022-07-06
标题:A kind of synthesis technique of 2'-O-(2-methoxyethyl)guanosine

专利号:CN-114835765-A
优先权日:2022-07-06
标题 :A kind of synthesis technique of 2,-O-(2-methoxyethyl) guanosine

专利号:CN-119930712-A
优先权日:2023-11-02
标 题 :New synthesis method of 2' -O-alkyl guanosine