CAS: 161712-75-0; 3-(3,4-Difluorophenyl)Propanoic Acid

相似化合物

301185-99-9 886499-50-9 458-45-7

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CAS号161712-77-2 5,6-二氟-1-茚酮 | CAS号803687-25-4 3-(3,4-DIFLUORO... | CAS号881190-18-7 6,7-二氟-2,3-二氢茚-1-酮

📜3,4-Difluorocinnamic Acid置于四丁基硫酸氢铵体系中,用 二甲基亚砜 用作溶剂,化学反应 10.0H,以78%的收率获得3-(3,4-二氟苯基)丙酸
参考文献:一种选择性还原α,β-不饱和羰基化合物中碳碳双键的方法
标题:一种选择性还原α,β-不饱和羰基化合物中碳碳双键的方法
摘要:本发明公开了一种选择性还原α,β‑不饱和羰基化合物中碳碳双键的方法,包括以下步骤:在电解体系中,加入式(I)所示的α,β‑不饱和羰基化合物,通过电化学阴极还原反应将α,β‑不饱和羰基化合物中与羰基共轭的碳碳双键还原;与已经报道的方法相比,本发明不使用金属催化剂和外部氧化剂;本发明所使用的反应原料和电解质价格低廉,无毒无味,后处理简便,因此适用工业化生产;本发明反应条件温和,操作简单且收率高,是一种高效实用的酯类和酰胺类化合物的合成方法.

专利信息

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:WO-2015088564-A1
优先权日:2013-12-13
标 题:P2x4 receptor modulating compounds
发明人：NEWCOM JASON S; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.