对甲氧基苯乙酸置于硫酸,碳酸氢钠体系中,用 乙醇,二氯甲烷,水 用作溶剂,化学反应生成对甲氧基苯乙酸乙酯 参考文献:Venlafaxine Production Process 标题:Venlafaxine Production Process 摘要:一种制备文拉法辛及/或其生理上可接受的盐的方法,包括将通式(II)中r为c1-C10烷基,芳基,芳基烷基或环烷基,碳原子数为3至6的化合物与通式(III)中x为卤素的有机镁化合物反应,如果需要,通过将所得文拉法辛与生理上可接受的酸反应形成所述盐.
专利号:DE-102012224021-A1 优先权日:2012-05-09 标 题 :A process for the synthesis of phenylacetic acid by carbonylation of toluene
专利号:JP-2013234166-A 优先权日:2012-05-09 标 题 :Synthesis of phenylacetic acid by carbonylation of toluene
专利号:US-6992097-B2 优先权日:1998-08-18 标 题 :Growth hormone secretagogues 发明人:HAUSER KENNETH LEE; DODGE JEFFREY ALAN; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR III CHARLES WILLIS; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROGER LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE 权利人:LILLY CO ELI 摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.