CAS: 1250038-98-2; 2-Chloro-N-Cyclopropyl-6-Methylpyrimidin-4-Amine

相似化合物

945895-52-3 1249743-25-6 270929-28-7

📜2,4-二氯-6-甲基嘧啶,环丙胺置于n,N-二异丙基乙胺体系中,用 乙醇 用作溶剂,化学反应 2.0H,反应生成2-氯-N-环丙基-6-甲基-4-嘧啶胺
参考文献:A Natural Product Inspired Hybrid Approach Towards The Synthesis Of Novel Pentamidine Based Scaffolds As Potential Anti-Parasitic Agents
标题:A Natural Product Inspired Hybrid Approach Towards The Synthesis Of Novel Pentamidine Based Scaffolds As Potential Anti-Parasitic Agents
摘要:A Natural Product Inspired Molecular Hybridization Approach Led Us To A Series Of Novel Pentamidine Based Pyrimidine And Chalcone Scaffolds. All The Hybrids Were Evaluated For Their Anti-Leishmanial Potential. Most Of The Screened Compounds Have Showed Significant In Vitro Anti-Leishmanial Activity With Less Cytotoxicity In Comparison To The Standard Drugs (Pentamidine,Sodium Stibogluconate,And Miltefosine). Additionally,Anti-Malarial Screening Of These Compounds Was Also Done And Four Compounds Have Shown Superior Activity Against Chloroquine Resistance Strain (K1) Of Plasmodium Falciparum. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2012.10.101