CAS: 118-75-2; Tetrachloro-1,4-Benzoquinone

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CAS号87-87-6 四氯氢醌 | CAS号87-86-5 五氯苯酚 | CAS号118-74-1 六氯苯 | CAS号123-31-9 对苯二酚 | CAS号88-06-2 2,4,6-三氯苯酚 | CAS号106-50-3 对苯二胺 | CAS号106-51-4 苯醌 | CAS号123-30-8 对氨基苯酚 | CAS号87-82-1 六溴苯 | CAS号112146-01-7 9-(2-methylprop... | CAS号87-87-6 四氯氢醌 | CAS号4316-35-2 (1,1-二甲氧基乙基)苯 | CAS号3858-78-4 正丁胺盐酸盐 | CAS号595-33-5 醋酸甲地孕酮 | CAS号492-80-8 碱性嫩黄 | CAS号14118-06-0 1,2,4-trichloro... | CAS号92-24-0 并四苯 | CAS号502-55-6 二黄原酸

五氯酚置于[双(三氟乙酰氧基)碘]苯体系中,用 乙醇,水 用作溶剂,化学反应 1.0H,反应生成四氯苯醌
参考文献:Optimization And Characterization Of A Flow Injection Electrochemical System For Pentachlorophenol Assay
标题:Optimization And Characterization Of A Flow Injection Electrochemical System For Pentachlorophenol Assay
摘要:开发并优化了一种流动注射(fi)电化学检测系统,用于测定受污染土壤中的五氯酚(pcp).在0.1 M酒石酸,Ph 2.0和室温下,使用双(三氟乙酸氧基)碘苯将pcp高效氧化为四氯-1,4-苯醌(1,4-Tcbq).在与固定化的葡萄糖氧化酶迅速反应后,检测和放大方案完成,1,4-Tcbq的还原形式或四氯-1,4-氢醌在玻碳电极表面被重新氧化为1,4-Tcbq(+ 0.40 V与ag/agcl相比).酶与葡萄糖底物之间的快速电子交换为电极提供了非速率限制的电流.Fi电化学系统对氧化pcp在1 μm范围内线性响应,检测限为10 Nm,并在连续操作14小时的165次重复分析中表现出+/-0.6%的重现性.当应用于pcp污染的土壤样品时,Fi电化学系统获得的结果与HPLC标准方法的结果较为一致.
Doi:10.1021/ac980266C

专利信息

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-2013267680-A1
优先权日:2010-09-15
标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof
发明人：OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL
权利人:OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL; STICHTING HET NL KANKERINST
摘要:The present invention relates to the field of total chemical synthesis of ubiquitin and related peptides. More in particular, a method is provided of solid phase synthesis of ubiquitin, ubiquitin mutants and derivatives thereof. It was the object of the present invention to provide an approach for the total chemical synthesis of ubuiqitin, which allows for the chemical synthesis of virtually any Ub mutant and giving high overall efficiency and purity. The present inventors have surprisingly found that this object can be realized with a method relying on incorporation of special amino acid building blocks. This approach was found to allow for exceptionally high yields of up to 14% and to provide an synthetic entry into virtually any ubiquitin derivative.

专利号:US-8084569-B2
优先权日:2006-12-21
标 题 :Process for the synthesis of diaminopyridines from glutarimidines
发明人：MINTER AARON; STOKES BERLIN
权利人:MINTER AARON; STOKES BERLIN; DU PONT
摘要:A liquid-phase process is provided for the synthesis from glutarimidines of diaminopyridines and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.

专利号:US-6251689-B1
优先权日:1998-05-14
标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
发明人：LABORDE EDGARDO; MATSUMOTO YUKIHARU
权利人:TELIK INC
摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.

专利号:US-7714063-B2
优先权日:2007-11-15
标 题 :Solid support for Fmoc-solid phase synthesis of peptides
发明人：SRIVASTAVA KRIPA SHANKER; DAVIS MATTHEW RYAN
权利人:MALLINCKRODT INC
摘要:The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing solid supports for the synthesis of polypeptides.

专利号:US-8022167-B2
优先权日:2006-12-21
标 题 :Process for the synthesis of diaminopyridines from glutaronitriles
发明人：MINTER AARON; STOKES BERLIN
权利人:MINTER AARON; STOKES BERLIN
摘要:A liquid-phase process is provided for the manufacture from glutaronitriles and related compounds of 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.