CAS: 928038-44-2; Azetidin-3-Ylmethanol Hydrochloride

该化合物是有机合成和制药研究中使用的多用途杂交环构件.该化合物的特性是四环乙二醇环,由四人组成,含氮环环,具有结构僵化性和潜在的生物活性.三点的氢乙基甲基组增强了其反应性,有利于开发新型药物候选体或农用化学物.盐的盐状进一步功能化,提高了稳定性和溶性,便利了合成应用的处理.该化合物在药用化学中对于针对...

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95849-02-8 618446-42-7 942308-06-7

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CAS号72351-36-1 1-二苯甲基-3-羟甲基-氮杂环丁烷 | CAS号99025-94-2 N-苄基-3-(羟基甲基)氮杂环丁烷 | CAS号142253-56-3 3-羟甲基氮杂环丁烷-1-羧酸叔丁酯

合成工艺路线路线简述

  • 142253-56-3 = 928038-44-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate; 2 H,25 °C
    标题:Sulfonamide-Nitrogen Oxide Derivatives As Pde-5 And Pde-6 Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Eye Diseases
    参考文献:World Intellectual Property Organization]

    142253-56-3 = 928038-44-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Dichloromethane,1,4-Dioxane; 1 H,15 °C
    标题:Rapidly Accelerating Fibrosarcoma Protein Degrading Compounds And Associated Methods Of Use
    参考文献:World Intellectual Property Organization]

    99025-94-2 = 928038-44-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Dihydroxide Solvents: Methanol; 24 H,Rt1.2 Reagents: Hydrochloric Acid
    标题:Azetidine Based Transition State Analogue Inhibitors Of N-Ribosyl Hydrolases And Phosphorylases
    作者:Evans,Gary B.; Furneaux,Richard H.; Greatrex,Ben; Murkin,Andrew S.; Schramm,Vern L.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2008 卷标:51(4) 页码:948-956]

    142253-56-3 = 928038-44-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; 2 H,Rt
    标题:Preparation Of Nitrogen Containing Bicyclic Compounds As Somatostatin Modulators,Especially Sstr2 Agonists,And Their Therapeutic Use
    参考文献:World Intellectual Property Organization]

    = 928038-44-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Dihydroxide Solvents: Methanol; 0.4 Mpa,Rt1.2 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate
    标题:Novel Pyridine Derivatives And Pyrimidine Derivatives As Hgfr Inhibitors And Their Preparation And Use In The Treatment Of Diseases
    参考文献:United States]

    72351-36-1 = 928038-44-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Dihydroxide Solvents: Methanol; 0.4 Mpa,Rt1.2 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate; Rt
    标题:Preparation Of Pyridine Or Pyrimidine Derivatives As Antitumor Agents Having Excellent Cell Growth Inhibition Effect And Excellent Antitumor Effect On Cell Strain Having Amplification Of Hgfr Gene
    参考文献:World Intellectual Property Organization]

    = 928038-44-2 [标题:Reaction Conditions
    标题:Preparation Of Aminopyrazine Derivatives As Jak2 Tyrosine Kinase Inhibitors
    参考文献:World Intellectual Property Organization]

    = 928038-44-2 [标题:Reaction Conditions
    标题:Preparation Of Pyridines And Pyrimidines Having Cyclopropane-1,1-Dicarboxamide Moiety As Hgfr Inhibitors
    参考文献:World Intellectual Property Organization]

    142253-56-3 = 928038-44-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate; 2 H,25 °C
    标题:Preparation Of Benzenesulfonamides Linked To A Fused Heteroaryl As Nitrogen Oxide-Donating Pde-5 And/or Pde-6 Inhibitors
    参考文献:World Intellectual Property Organization]

    142253-56-3 = 928038-44-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Dichloromethane,1,4-Dioxane; 2 H,20 °C
    标题:Benzofuran Analogues As Ns4B Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Hcv
    参考文献:China]

    142253-56-3 = 928038-44-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Dichloromethane,1,4-Dioxane; 2 H,20 °C
    标题:Benzofuran Analogue As Ns4B Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Hepatitis C
    参考文献:World Intellectual Property Organization]

    99025-94-2 = 928038-44-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Dihydroxide Solvents: Methanol; 24 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Preparation,Nucleosidase And Phosphorylase Inhibition Of Azetidine Nucleoside Analogs
    参考文献:World Intellectual Property Organization]

    142253-56-3 = 928038-44-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Dichloromethane; 2 H,25 °C
    标题:Preparation Of Indazole Based Bifunctional Molecules As Selective Modulators Of Mutant Lrrk2 For Treatment Of Neurodegenerative Disorders
    参考文献:World Intellectual Property Organization]

    142253-56-3 = 928038-44-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Ethyl Acetate; 2 H,Rt
    标题:Preparation Of Modified Andrographolides Useful For The Treatment Of Inflammation
    参考文献:China]

    72351-36-1 = 928038-44-2
    反应条件:1.1 Reagents: Hydrogen,Hydrochloric Acid Catalysts: Palladium Solvents: Methanol,Water; Overnight,4 Bar,45 °C
    标题:Effect Of Lipophilicity Modulation On Inhibition Of Human Rhinovirus Capsid Binders
    作者:Morley,Andrew; Tomkinson,Nicholas; Cook,Andrew; Macdonald,Catherine; Weaver,Richard; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2011 卷标:21(20) 页码:6031-6035]

    72351-36-1 = 928038-44-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Hydroxide Solvents: Methanol; 0.4 Mpa,Rt1.2 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate
    标题:Preparation Of Phenoxypyridine Derivatives As Hgfr Inhibitors For Treatment Of Cancer
    参考文献:World Intellectual Property Organization]

    = 928038-44-2 [标题:Reaction Conditions
    标题:Preparation Of Taxane Compounds With Azetidine Ring Structure As Anticancer Agents
    参考文献:World Intellectual Property Organization
📜3-羟甲基氮杂环丁烷-1-羧酸叔丁酯置于盐酸体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 2.0H,以0.66 G的收率获得产物3-甲羟基氮杂环丁烷盐酸盐
参考文献:Somatostatin Modulators And Uses Thereof
标题:Somatostatin Modulators And Uses Thereof
摘要:本文描述了一些肽类调节剂化合物,制备这类化合物的方法,包含这类化合物的药物组合物和药物,以及利用这类化合物治疗需要调节生长抑素活性的疾病,症状或疾病的方法.

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[参考文献]: Yi L, Et, Al. Substituted Pyrazine Compound, Pharmaceutical Composition Comprising Same, And Use Thereof. Wo2021259077A1.
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