CAS: 75143-89-4; 3-Isobutylglutaric Acid

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CAS号181289-33-8 (R)-(-)-3-(氨甲酰甲... | CAS号51615-30-6 Propanedioic ac... | CAS号181289-34-9 (3S)-3-(2-amino... | CAS号181289-15-6 3-(氨甲酰甲基)-5-甲基己酸 | CAS号148553-50-8 普瑞巴林 | CAS号181289-33-8 (R)-(-)-3-(氨甲酰甲... | CAS号128013-69-4 3-(氨甲基)-5-甲基己酸 | CAS号185815-59-2 3-异丁基戊二酸酐 | CAS号185815-61-6 (R)-3-(羰基甲基)-5-甲基己酸

Diethyl 3-Isobutylglutarate置于盐酸体系中,用 水 作为反应溶剂,化学反应 4.0H,以91%的收率获得产物3-丁基戊二酸
参考文献:一种制备3-异丁基戊二酸的方法
标题:一种制备3-异丁基戊二酸的方法
摘要:本发明公开了一种制备3‑异丁基戊二酸的方法,包括将异戊醛和丙二酸二乙酯以六氢吡啶乙酸盐为催化剂,在环己烷溶剂中进行knoevenagel缩合反应;将第一步所得产物在由氯化钠,Dmso和水组成的溶液中进行加热脱羧反应;将第二步所得产物和丙二酸二乙酯在碱的醇溶剂中进行迈克尔加成和脱羧反应;将第三步所得产物在酸性条件下进行水解反应,得到3‑异丁基戊二酸产品.本发明以廉价易得的异戊醛和丙二酸二乙酯为原料,克服了现有技术中5‑甲基‑2‑氰基‑2‑己烯酸酯中碳碳双键的空间位阻大的缺陷,缩短反应时间,提高了异戊醛的反应转化率,由此保证了3‑异丁基戊二酸产品的总收率.

专利信息

专利号:US-2007259917-A1
优先权日:2006-04-24
标题 :Processes for the synthesis of 3-isobutylglutaric acid
发明人：KANSAL VINOD K; CHAURASIA BRIJNATH P; PATEL HITESH K; SHELKE SHIVAJI H; MORE YOGESH P
权利人:KANSAL VINOD K; CHAURASIA BRIJNATH P; PATEL HITESH K; SHELKE SHIVAJI H; MORE YOGESH P
摘要:Provided are processes for the synthesis of 3-isobutylglutaric acid, an intermediate in the synthesis of (S)-Pregabalin.

专利号:US-2010087525-A1
优先权日:2008-06-23
标 题:Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
发明人：HEDVATI LILACH; STERIMBAUM GRETA; RAIZI YURIY; AMINOV RAHAMIN
权利人:HEDVATI LILACH; STERIMBAUM GRETA; RAIZI YURIY; AMINOV RAHAMIN
摘要:The present invention relates to a stereoselective enzymatic synthesis of (S) or (R)-iso-butyl-glutaric ester, an intermediate of S-Pregabalin.

专利号:US-8212071-B2
优先权日:2005-09-19
标题:Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
发明人：KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; RAO V GOVARDHAN; TIWARI ANAND PRAKASH
权利人:KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; RAO V GOVARDHAN; TIWARI ANAND PRAKASH; TEVA PHARMA
摘要:The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin.

专利号:US-7462738-B2
优先权日:2006-05-24
标题:Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
发明人：HEDVATI LILACH; GILBOA EYAL; AVHAR-MAYDAN SHARON
权利人:TEVA PHARMA
摘要:Provided are processes for the synthesis of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof, intermediates in the synthesis of S-pregabalin.

专利号:US-2009081801-A1
优先权日:2007-08-15
标题:Process for synthesis of pyrrole derivative, an intermediate for atorvastatin
发明人：KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; PATEL HITESH K; RAO V GOVARDHAN; DAUND VAIBHAV S
权利人:KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; PATEL HITESH K; RAO V GOVARDHAN; DAUND VAIBHAV S
摘要:The present invention also relates to a novel impurity, (6-{2-[2-(6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxan-4-yl)-acetylamino]-ethyl}-2,2-dimethyl-[1,3]-dioxan-4-yl)-acetic acid tert-butyl ester, the compound of formula IV, having the following structure: n n n n n n n n n n The present invention also provides methods of preparing the compound of formula IV as well as methods of using the compound of formula IV as a reference marker and a reference standard. n The present invention also provides an improved process for preparing (4R,cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrole-1-yl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester, the compound of formula I, said process comprising the step of condensing 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzene butanamide, the compound of formula III, with (4R,Cis)-1,1-dimethylethyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate, the compound of formula II, in the presence of a catalytic amount of an acid in the presence of a solvent system, preferably a binary solvent system, to obtain the desired compound (4R,cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrole-1-yl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester.

专利号:US-8168828-B2
优先权日:2007-06-25
标题 :Process for the preparation of pregabalin
发明人：SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; SATYANARAYANA REVU
权利人:SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; SATYANARAYANA REVU; MSN LAB LTD
摘要:The present invention encompasses novel intermediates of pregabalin, namely 3-cyano-5-methyl hexanamide (28) and 3-(amino methyl)-5 methyl hexanamide (29), and processes for their preparation. The invention also encompasses a process for converting the novel pregabalin intermediates into pregabalin, Formula (I): The present invention further provides a cost effective method for the synthesis of (S)-pregabalin, which involves the recovery of mandelic acid and tartaric acid used in the resolution process and recycling them, increasing the yields of the final product formed, which substantially reduced the cost of the production.