CAS: 7396-44-3; Benzyl 2-(Diethoxyphosphoryl)Acetate

上下游产品

CAS号122-52-1 亚磷酸三乙酯 | CAS号5437-45-6 溴乙酸苄酯 | CAS号3095-95-2 二乙基磷乙酸 | CAS号100-39-0 溴化苄 | CAS号79-37-8 草酰氯 | CAS号762-04-9 亚磷酸二乙酯 | CAS号140-18-1 氯乙酸苄酯 | CAS号2303-76-6 diethyl sodium ... | CAS号867-13-0 磷酰基乙酸三乙酯 | CAS号3095-95-2 二乙基磷乙酸 | CAS号103-41-3 肉桂酸苄酯 | CAS号77530-34-8 (2-oxo-2-phenyl... | CAS号62591-74-6 benzyl 2-bis(tr... | CAS号52039-22-2 benzyl 2-amino-...

磷酰基乙酸三乙酯置于caesium Carbonate,Sodium Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应 2.0H,反应生成 二乙基膦酰基乙酸苄酯
参考文献:Synthesis Of Orthogonally Protected (2S)-2-Amino-Adipic Acid (α-Aaa) And (2S,4R)-2-Amino-4-Hydroxyadipic Acid (Ahad)
标题:Synthesis Of Orthogonally Protected (2S)-2-Amino-Adipic Acid (α-Aaa) And (2S,4R)-2-Amino-4-Hydroxyadipic Acid (Ahad)
摘要:(2S,4R)-2-氨基-4-羟基己二酸(ahad)结构单元45由市售材料经11步反应,6.5%的整体收率合成.手性控制的关键步骤包括采用脯氨酸基催化剂进行的不对称共轭加成,以及氧亲核试剂对α,β-不饱和酯的syn选择性分子内共轭加成.为了实现α-氨基己二酸(α-Aaa)和ahad在肽中的掺入,开发了一种真正正交的保护基方案:包括用于n-端的烯丙氧基羰基(alloc)碳酸酯,用于δ-羧酸的叔丁氧基酯,用于α-羧酸的乙酰氧基酯以及用于ahad中γ-羟基的叔丁基二甲基硅醚保护基.
DOI:10.1021/jo400558T

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-5641798-A
优先权日:1993-10-18
标题 :Bicyclic compounds and their use as excitatory amino acid receptor antagonists
发明人：MONN JAMES A
权利人:LILLY CO ELI
摘要:This invention provides novel bicyclic compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides intermediates useful in the synthesis of excitatory amino acid antagonists.

专利号:US-5675008-A
优先权日:1992-09-03
标 题 :Excitatory amino acid receptor antagonists
发明人：BERTSCH CARL F; HUFF BRET; MARTINELLI MICHAEL J; ORNSTEIN PAUL L
权利人:LILLY CO ELI
摘要:This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.