CAS: 73346-74-4; ((4R,5R)-2,2-Dimethyl-1,3-Dioxolane-4,5-Diyl)Dimethanol

该化合物是有机合成和制药应用中广泛使用的一个手动建筑块,其主要优势在于其硬性异丙基保护二醇结构,它加强了对非对称反应的立体化学控制.该化合物是合成核糖,糖和其他生物活性分子的多功能中间体.在各种反应条件下,它高纯度和稳定性使它成为复杂的合成途径的可靠选择.此外,受保护的二醇功能允许有选择地去保护,从而能够进一步实现功能化.该化合物在药用化学中特别有用,用于建造对分子相容进行精确控制的定型框架.

结构式图片

上下游产品

CAS号37031-29-1 (-)-二甲基-2,3-邻异丙... | CAS号73346-73-3 (4S,5S)-2,2-二甲基... | CAS号3969-84-4 3,4-O-异亚丙基-D-甘露糖醇 | CAS号59779-75-8 (R,R)-O,O-异丙基酒石酸二乙酯 | CAS号5754-27-8 (4S,5S)-2,2-dim... | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号3969-59-3 三丙酮甘露糖醇 | CAS号109715-58-4 2,2-dimethyl-3a... | CAS号51064-65-4 1,4-甲苯磺酰基-2,3-异... | CAS号73711-65-6 ((4R,5R)-5-(hyd... | CAS号139165-54-1 1,4-二氯丁烷-2S-3S-二醇

合成工艺路线路线简述

    Mannitol Triacetonide置于sodium Tetrahydroborate,Sodium Periodate,溶剂黄146体系中,化学反应 4.5H,反应生成 (-)-2,3-O-亚异丙基-D-苏力糖醇
    参考文献:Holy,Antonin,Collection Of Czechoslovak Chemical Communications,1982,Vol. 47,# 1,P. 173-189
    标题:Holy,Antonin,Collection Of Czechoslovak Chemical Communications,1982,Vol. 47,# 1,P. 173-189

    海关参考信息

    专利信息


    专利号:US-10266565-B2
    优先权日:2011-04-12
    标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
    发明人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
    权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
    摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

    专利号:US-8580975-B2
    优先权日:2008-01-11
    标 题:Synthesis of macrocyclic cancer chemotherapy agents and methods of use
    发明人:GHOSH ARUN K; XU XIAOMING
    权利人:GHOSH ARUN K; XU XIAOMING; PURDUE RESEARCH FOUNDATION
    摘要:Herein are described a process for forming a quaternary carbon useful in the preparation of macrolactones, an enantioselective synthesis of (+)-peloruside A, and methods for treating a patient in need of relief from cancer or a cancer-related disease. The described processes are useful for preparing compounds containing quaternary carbons, including structural analogs and derivatives of peloruside A.

    专利号:US-5880295-A
    优先权日:1994-02-16
    标 题 :Process for the preparation of diamine intermediates useful in the synthesis of HIV protease inhibitors
    发明人:KALTENBACH III ROBERT FRANK
    权利人:DU PONT PHARM CO
    摘要:The present invention provides a process for the preparation of compounds of formula (V) below, and analogs thereof, which are useful as intermediates for the synthesis of HIV protease inhibitors, including cyclic ureas. ##STR1##

    专利号:WO-2009089450-A1
    优先权日:2008-01-11
    标题:Synthesis of macrocyclic cancer chemotherapy agents and methods of use

    专利号:EP-2242502-A1
    优先权日:2008-01-11
    标题:Synthesis of macrocyclic cancer chemotherapy agents and methods of use

    专利号:US-6573388-B1
    优先权日:1999-08-18
    标 题:Ethylaziridine derivatives and their preparation methods
    发明人:KIM BYUNG MOON; BAE SUNG JIN; SO SOON MOK; KANG JAE SUNG; LEE JOONG HWAN
    权利人:SAMCHULLY PHARM CO LTD
    摘要:This invention is related to new ethylaziridine derivatives of formula (I) and their preparation. The compounds are useful synthetic intermediates for the synthesis of HIV protease inhibitors and oligopeptide mimetics.
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    合成参考文献


    摘要:Petursson, S., Science of Synthesis, (2008) 37, 860.
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