CAS: 611-59-6; 1,7-Dimethyl-1H-Purine-2,6(3H,7H)-Dione

该化合物是一种甲基苯丙胺衍生物和咖啡因代谢物,其特点是化学结构,包括一个纯碱基,其中含有与1,3和7号据点氮原子相连的三个甲基组,与咖啡因相似,以其刺激性特性著称,主要存在于人体,并因咖啡因代谢而发现;它具有各种药理效应,包括增加热解和增强物理性能,使其对营养和体育科学环境都感兴趣;Paraxanthine在水中溶解,具有相对较低的毒性特征;它在中央...

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上下游产品

H-imidazole-4-carboxylic acid methylamide5-amino-3-methyl-3H-imidazole-4-carboxylic acid methylamide chloroformic acid ethyl ester 1,7-dimethyl-2-thioxo-1,2,3,7-tetrahydro-purin-6-one 8-chloro-1,7-dimethyl-1H-purine-2,6(3H,7H)-dione 3-isopropyl-1,7-dimethyl-3,7-dihydro-purine-2,6-dione 1,7-Dimethyl-3-benzylxanthine 3-Propyl-1,7-dimethylxanthine 3-allyl-1,7-dimethyl-3,7-dihydro-purine-2,6-dione

合成工艺路线路线简述

  • 合成目标产物 1,7-Dimethylxanthine 主要起始原料 1H-Purine-2,6-Dione,3,7-Dihydro-1,7-Dimethyl-3-(Phenylmethyl)-
  • (文献来源)合成步骤主要原料 1H-Purine-2,6-Dione,3,7-Dihydro-1,7-Dimethyl-3-(Phenylmethyl)-
鸟苷置于盐酸,Sodium Methylate,溶剂黄146,Sodium Nitrite体系中,用 N-甲基吡咯烷酮,甲醇,乙醇,水 作为反应溶剂,化学反应 1.0H,反应生成 1,7-二甲基黄嘌呤
参考文献:一种副黄嘌呤的制备方法
标题:一种副黄嘌呤的制备方法
摘要:本发明公开了一种副黄嘌呤的制备方法,将鸟嘌呤核苷(V)的7位和1位n甲基化后水解糖基得到化合物(II),再将化合物(II)与重氮化试剂反应后水解得到副黄嘌呤(I).本发明的原辅料均廉价易得,主原料鸟嘌呤核苷工业价格仅90元/kg;步骤短,总收率>=70%;均为常规转化,反应条件温和,安全可靠;操作简便,工艺稳定,适合工业化.

专利信息


专利号:WO-2022229983-A1
优先权日:2021-04-29
标题:Sugar esters and sugar alcohol esters of short chain fatty acids and compositions thereof
发明人:KANUMURU RAHUL RAJU; SHAJI GEORGE KOCHUMALAYIL; ANINDYA SIL; SURANENI RAVIKUMAR; GARUDADRI LAKSHMI PRASANNA KUMAR
权利人:FERTIS INDIA PVT LTD
摘要:The present invention discloses compositions comprising sugar esters and sugar alcohol esters of short chain fatty acids and their use in pest management. These compositions possess antiviral, antimicrobial, insecticidal, pesticidal and herbicidal properties and their potential use in controlling, Lepidoptera, Hemiptera and Thysanoptera insects, Tomato spotted wilt viruses, Tobacco mosaic viruses. The present invention also dicloses compositions of sugar esters and sugar alcohol esters of short chain fatty acids as potential agents for treating oral and dermatological problems of microbial origin. The present invention further discloses the synthesis of novel sugar esters and sugar alcohol esters of short chain fatty acids.

专利号:WO-2025133718-A1
优先权日:2023-12-22
标题 :An efficient process for the synthesis of paraxanthine
发明人:KANUMURU RAHUL RAJU; KOCHUMALAYIL SHAJI GEORGE; SURANENI RAVIKUMAR; VANA MURALI MOHANARAO
权利人:FERTIS INDIA PVT LTD
摘要:The processes disclosed are simple, economical for large scale industrial production resulting in high purity and quality of paraxanthine. Further the process produces high-purity paraxanthine suitable for various applications in the nutraceutical, pharmaceutical, and cosmetic industries.

专利号:WO-2024121871-A1
优先权日:2022-12-09
标 题 :Genetic modification of microbes for production of nitrogen and carbon-containing compounds
发明人:KANUMURU RAHUL RAJU
权利人:FERTIS INDIA PVT LTD
摘要:The present invention relates to a novel method for sustainable in vitro and in vivo production of nitrogen and carbon containing compounds such as and not limited to Proteins, Enzymes, peptides amino acids, nucleotides, vitamins, etc. The present invention relates to a novel method that includes gene modifications in microbes, more specifically involving gene modifications resulting in nitrogen fixation and/or ammonia fixation or increased nitrogen fixation and/or ammonia fixation or carbon fixation/increased carbon fixation or Hydrogen fixation/increased Hydrogen fixation with increased synthesis/ regeneration of anyone or all compounds including ATP, NADH, NADPH, Pyruvate and Acetyl CoA with or without utilisation/reduction enhanced utilisation/reduction of Nitrate, Nitrite, N2O, N2O2 and/or carbon containing substrates

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

专利号:US-6930227-B1
优先权日:1999-05-26
标题:Camellia sinensis gene encoding a caffeine synthesis associated n-methyl transferase with 7-methylxanthine n3 methyl transferase, theobromine n1 methyl transferase, and paraxanthine n3 methyl transferase activities and use thereof
发明人:MIZUNO MISAKO; ASHIHARA HIROSHI; MIZUNO KOUICHI; FUJIMURA TATSUHITO
权利人:MITSUI CHEMICALS INC
摘要:The present invention makes it possible to efficiently produce an N-methyl transferase with 7-methylxanthine N3 methyl transferase, theobromine N1 methyl transferase, and paraxanthine N3 methyl transferase activities that can be utilized as an industrial, food, or medical enzyme. In addition, the present invention makes it possible to modify the caffeine biosynthesis metabolism of caffeine producing plants, plant tissues, or plant cells, thereby efficiently producing caffeine metabolism based compounds or modifying the production of caffeine in the plants.

专利号:CN-108753740-A
优先权日:2018-06-25
标 题 :Enzyme composition for catalyzing the synthesis of theobromine and its application in biological preparation of theobromine
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主要参考文献


1: Szlapinski SK, Charrette A, Guthrie N, Hilmas CJ. Paraxanthine safety and comparison to caffeine. Front Toxicol. 2023 Feb 2;5:1117729. doi: 10.3389/ftox.2023.1117729.
2: Jäger R, Purpura M, Wells SD, Liao K, Godavarthi A. Paraxanthine Supplementation Increases Muscle Mass, Strength, and Endurance in Mice. Nutrients. 2022 Feb 20;14(4):893. doi: 10.3390/nu14040893.
3: Purkiewicz A, Pietrzak-Fiećko R, Sörgel F, Kinzig M. Caffeine, Paraxanthine, Theophylline, and Theobromine Content in Human Milk. Nutrients. 2022 May 25;14(11):2196. doi: 10.3390/nu14112196.

合成参考文献


参考文献:10.1007/s00228-010-0785-6
摘要:Djordjevic N, Carrillo JA, Gervasini G, Jankovic S, Aklillu E. In vivo evaluation of CYP2A6 and xanthine oxidase enzyme activities in the Serbian population. European Journal of Clinical Pharmacology. 2010 Feb 13;66(6):571–8. doi: 10.1007/s00228-010-0785-6.
参考文献:10.1007/s00216-010-3506-1
摘要:Carvalho JJ, Weller MG, Panne U, Schneider RJ. A highly sensitive caffeine immunoassay based on a monoclonal antibody. Analytical and Bioanalytical Chemistry. 2010 Feb 16;396(7):2617–28. doi: 10.1007/s00216-010-3506-1.
参考文献:10.1136/thx.2010.156695
摘要:Ibrahim B, Basanta M, Cadden P, Singh D, Douce D, Woodcock A, Fowler SJ. Non-invasive phenotyping using exhaled volatile organic compounds in asthma. Thorax. 2011 Sep;66(9):804–9. doi: 10.1136/thx.2010.156695.
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