CAS: 60547-97-9; 6,7-Dimethoxy-2-(Piperazin-1-yl)Quinazolin-4-Amine

上下游产品

CAS号110-85-0 哌嗪 | CAS号23680-84-4 4-氨基-2-氯-6, 7-二氧基喹唑啉 | CAS号107021-36-3 普拉佐宾德 | CAS号74191-85-8 多沙唑嗪 | CAS号19237-84-4 盐酸哌唑嗪 | CAS号19216-56-9 哌唑嗪 | CAS号79221-43-5 1-Piperazinecar...

2-氯-4-氨基-6,7-二甲氧基喹唑啉置于macroporous Polymer-Supported Carbonate,Macroporous Polymer-Supported-Tsoh体系中,用 二氯甲烷,二甲基亚砜 作为反应溶剂,化学反应生成 2-哌嗪基-4-氨基-6,7-二甲氧基喹唑啉
参考文献:Parallel Synthesis Of N-Arylpiperazines Using Polymer-Assisted Reactions
标题:Parallel Synthesis Of N-Arylpiperazines Using Polymer-Assisted Reactions
摘要:A Series Of N-Arylpiperazines Were Prepared In A Parallel Fashion Using Palladium-Catalyzed Cross-Coupling,Or Nucleophilic Aromatic Displacement Chemistries,And Polymer-Assisted Sequestration And Purification Techniques As Key Steps. (C) 2006 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2006.02.047

专利信息

专利号:US-6469065-B1
优先权日:1996-02-02
标 题:Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
发明人：GARVEY DAVID S; SCHROEDER JOSEPH D; DE TEJADA INIGO SAENEZ; GASTON RICKY D; SHELEKHIN TATIANA E; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.

专利号:US-2005187222-A1
优先权日:1996-02-02
标题:Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds
发明人：GARVEY DAVID S; DE TEJADA INIGO S; GASTON RICKY D; KHANAPURE SUBHASH P; SHELEKHIN TATIANA E; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.