CAS: 52605-96-6; 2-Chloro-3-Methoxypyridine

相似化合物

1206977-80-1 1214340-74-5 1105933-54-7

上下游产品

diazomethane 2-chloro-3-hydroxypyridine 3-methoxy-1H-pyridin-2-one methyl iodide 2-ethyl-3-methoxypyridine 3-methoxy-2-methylpyridine 2,3-dimethoxypyridine 5-formyl-2,3-dimethoxypyridine

3-甲氧基吡啶置于盐酸,Potassium Permanganate体系中,用 水 作为反应溶剂,以10.20 G的收率获得产物2-氯-3-甲氧基吡啶
参考文献:一种卤代含氮不饱和环烃的制备方法
标题:一种卤代含氮不饱和环烃的制备方法
摘要:本发明公开了一种卤代含氮不饱和环烃的制备方法,步骤为:(1)将含氮不饱和环烃溶解于盐酸或氢溴酸中,加入氧化剂,使反应体系进行卤代反应,反应过程中定时取样检测,当检测到目标产物一卤化物的质量占比为反应体系内的总有机物的70%‑95%时,向反应体系内加入终止剂终止反应,便得到含有含氮不饱和环烃的料液;(2)向料液加入有机溶剂进行萃取,萃取后得到有机相,将有机相降温使其析出固体物或蒸馏有机相除去溶剂得到液体产物,所得固体物或液体产物为卤代含氮不饱和环烃.该方法很好的解决了含氮不饱和环烃过卤代化反应的问题.

专利信息

专利号:US-12060343-B2
优先权日:2018-10-22
标题 :Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors

专利号:US-2023391751-A1
优先权日:2018-10-22
标题 :Substituted 1,2,4-triazoles as intermediates in the synthesis of tyk2 inhibitors

专利号:US-7687487-B2
优先权日:2007-04-19
标题 :Camptothecin-analog with a novel, “flippedâ€? lactone-stable, E-ring and methods for making and using same
发明人：HAUSHEER FREDERICK H
权利人:BIONUMERIK PHARMACEUTICALS INC
摘要:The present invention discloses: (i) a novel, lactone-stable, “flippedâ€? E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof; (ii) methods of synthesis of said novel, lactone-stable, “flippedâ€? E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof; (iii) pharmaceutically-acceptable formulations comprising said novel, lactone-stable, “flippedâ€? E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more additional chemotherapeutic agents; (iv) methods of administration of said novel, lactone-stable, “flippedâ€? E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more additional chemotherapeutic agents, to subjects in need thereof; and (v) devices for the administration of said novel, lactone-stable, “flippedâ€? E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more chemotherapeutic aents, to subjects in need thereof.

专利号:US-7999090-B2
优先权日:2000-07-07
标 题:Fungal cell wall synthesis gene
发明人：TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.

专利号:EP-2007386-B1
优先权日:2006-04-19
标题 :Camptothecin-analog with a novel, flipped lactone-stable, e-ring and methods for making and using same
发明人：HAUSHEER FREDERICK H
权利人:BIONUMERIK PHARMACEUTICALS INC
摘要:The present invention discloses: (i) a novel, lactone-stable, “flippedâ€? E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof; (ii) methods of synthesis of said novel, lactone-stable, “flippedâ€? E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof; (iii) pharmaceutically-acceptable formulations comprising said novel, lactone-stable, “flippedâ€? E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more additional chemotherapeutic agents; (iv) methods of administration of said novel, lactone-stable, “flippedâ€? E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more additional chemotherapeutic agents, to subjects in need thereof; and (v) devices for the administration of said novel, lactone-stable, “flippedâ€? E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more chemotherapeutic aents, to subjects in need thereof.

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.