CAS: 51481-10-8; Deoxynivalenol

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CAS号50722-38-8 3-乙酰脱氧瓜萎镰菌醇 | CAS号88337-96-6 15-O-乙酰脱氧瓜萎镰菌醇 | CAS号56676-60-9 3,15-diacetyl-4... | CAS号50722-38-8 3-乙酰脱氧瓜萎镰菌醇 | CAS号88054-24-4 去环氧脱氧雪腐镰刀菌醇 | CAS号51550-28-8 Trichothec-9-en...

📜15-O-乙酰脱氧瓜萎镰菌醇置于sodium Hydroxide体系中,化学反应生成 脱氧雪腐镰刀菌烯醇
参考文献:Structure−activity Relationships Of Trichothecene Toxins In An Arabidopsis Thaliana Leaf Assay
标题:Structure−activity Relationships Of Trichothecene Toxins In An Arabidopsis Thaliana Leaf Assay
摘要:Many Fusarium Species Produce Trichothecenes,Sesquiterpene Epoxides That Differ In Patterns Of Oxygenation And Esterification At Carbon Positions C-3,C-4,C-7,C-8,And C-15. For The First Comprehensive And Quantitative Comparison Of The Effects Of Oxygenation And Esterification On Trichothecene Phytotoxicity,We Tested 24 Precursors,Intermediates,And End Products Of The Trichothecene Biosynthetic Pathway In An Arabidopsis Thaliana Detached Leaf Assay. At 100 Mu M,The Highest Concentration Tested,Only The Trichothecene Precursor Trichodiene Was Nontoxic. Among Trichothecenes,Toxicity Varied More Than 200-Fold. Oxygenation At C-4,C-8,C-7/8,Or C-15 Was,On Average,As Likely To Decrease As To Increase Toxicity. Esterification At C-4,C-8,Or C-15 Generally Increased Toxicity. Esterification At C-3 Increased Toxicity In One Case And Decreased Toxicity In Three Of Eight Cases Tested. Thus,The Increase In Structural Complexity Along The Trichothecene Biosynthetic Pathway In Fusarium Is Not Necessarily Associated With An Increase In Phytotoxicity.
DOI:10.1021/jf0709193

专利信息

专利号:US-2025147014-A1
优先权日:2022-02-14
标题:Plasmon-enhanced fluorescence biochemical sensors
发明人：PINCHUK ANATOLI; SERGEYEVA TETYANA; YARYNKA DARIA; CHEGEL VLADIMIR; LOPATYNSKYI ANDRI
权利人:UNIV COLORADO REGENTS; THE REGENTS OF THE UNIV OF COLORADO A BODY
摘要:A highly sensitive technology enabling selective recognition of aflatoxins such as in contaminated cereal samples. Methods for the synthesis of AgNP-containing MIP membranes from the monomer mixtures containing both methacrylate monomers and oligomers as well as AgNOs solution in dimethylformamide enable the detection system. The AgNP were formed in the structure of the polymeric membranes during the pre-heating step followed by the UV-initiated polymerization. The highly selective sensor elements where MIP membranes are combined with the Ag nanostructures as signal amplifiers (LSPR-MIP nanochips) can be stored separately and used with a simple optical recognition system as selective elements of point-of-care sensor devices, even in in-field conditions. Composite plasmonic membranes provide both highly selective recognition of the target toxin and the generation of an enhanced optical signal, allowing aflatoxin B1 detection at ultralow concentrations.

专利号:WO-2024227949-A1
优先权日:2023-05-04
标 题:Screening and uses of glutamine synthetase modulators
发明人：MARTINS GARCIA BRUNA; FARAH PERNAS LENA
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to an in vitro bioassay to identify glutamine synthetase activators and inhibitors on the basis of one or more glutamine markers such as citrate, a metabolite derived from the mevalonate pathway, a glutamine responsive mRNA or proteins, such as HMGCR or SREBP2. Disclosed herein are also glutamine synthetase activators and inhibitors identified by the inventive method for use to stimulate or inhibit the synthesis of a metabolite derived from the mevalonate pathway, such as cholesterol, and to treat a disease associated with deregulated levels of said metabolite, such as cancer.

专利号:US-2022249576-A1
优先权日:2021-02-09
标 题:Method of disrupting mycotoxin synthesis using a composition comprising vibrio gazogenes
发明人：CHANDA ANINDYA
权利人:Mycologics LLC
摘要:A method of inhibiting mycotoxin synthesis in filamentous fungi comprises contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC. Additionally, infections caused by filamentous fungi can be inhibited by contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC 43942. Endosomal function in filamentous fungi can be disrupted by contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC 43942. Hyphal fusion formation can be restricted in filamentous fungi by contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC 43942.

专利号:US-6060646-A
优先权日:1997-08-12
标题:Tolerance of trichothecene mycotoxins in plants and animals through the modification of the peptidyl transferase gene
发明人：HARRIS LINDA; GLEDDIE STEVE
权利人:CA MINISTER AGRICULTURE & FOOD
摘要:Fusarium graminearum is a plant pathogen, attacking a wide range of plant species including corn (ear and stalk rot), barley, and wheat (head blight). Fusarium epidemics result in millions of dollars of loses in crop revenues. Fusarium graminearum infection in the cereals reduces both grain yield and quality. Mycotoxins are produced by many fungal Fusarium species and thus the grain becomes contaminated with these mycotoxins, such as the trichothecenes. The major trichothecene produced by F. graminearum is deoxynivalenol (abbreviated as DON, also known as vomitoxin). Trichothecenes are potent protein synthesis inhibitors and are quite toxic to humans and livestock. A yeast gene has been identified which is resistant to the trichothecene, trichodermin. A corresponding plant gene has been prepared, which has been used to transform plants and would be suitable to transform animals. These transformed plants have an increased resistance to Fusarium infestation. Potentially, transformed animals could have an increased tolerance to the trichothecene mycotoxins.

专利号:US-6855872-B2
优先权日:1997-08-12
标题 :Tolerance of trichothecene mycotoxins in plants through the modification of the ribosomal protein L3 gene
发明人：HARRIS LINDA J; GLEDDIE STEPHEN C; SIMMONDS JOHN A
权利人:CA MINISTER AGRICULTURE & FOOD
摘要:Fusarium graminearum is a plant pathogen, attacking a wide range of plant species including corn (ear and stalk rot), barley, and wheat (head blight). Fusarium epidemics result in millions of dollars of losses in crop revenues. Fusarium graminearum infection in the cereals reduces both grain yield and quality. Mycotoxins are produced by many fungal Fusarium species and thus the grain becomes contaminated with these mycotoxins, such as the trichothecenes. The major trichothecene produced by F. graminearum is deoxynivalenol (abbreviated as DON, also known as vomitoxin). Trichothecenes are potent protein synthesis inhibitors and are quite toxic to humans and livestock. A yeast gene has been identified which confers upon yeast tolerant of the trichothecene, trichodermin. A corresponding plant gene has been prepared, which has been used to transform plants. These transformed plants have an increased resistance to Fusarium infestation.

专利号:CN-115553290-B
优先权日:2022-10-14
标题:Application of orange peel essential oil in inhibiting the synthesis of mycotoxins of wheat fusarium