CAS: 4814-74-8; 1-Hydroxy-1H-Pyrrole-2,5-Dione

该化合物是一种多用途化学试剂,主要用于生物合成和交叉连接应用.它的顺丁烯二烯基胺组可以对硫柳类进行选择性反应,在温和条件下促进稳定的硫醚结合形成,而N-Hydroxyl 组则能增强反应性和溶解性.这种复合剂由于其高度特殊性和效率,在蛋白标签,浸泡物改变和聚合物化学方面特别宝贵.它具有水溶剂的稳定性,并且与各种pH值条件相容性,因此适合多种生物化学和材料科学应用. N-HydroxyMemiide在创建定义清晰的侧反应最小的同源时,往往因其可靠性而更受青睐.

结构式图片

相似化合物

541-59-3 930-88-1 2973-17-3

欧盟法规

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CAS号60361-89-9 2,5-dioxo-2,5-d... | CAS号5596-17-8 外-N-羟基-7-氧杂二环[2... | CAS号58936-19-9 benzyl N-maleim...

合成工艺路线路线简述

    N-Hydroxy-3,6-Epoxy-1,2,3,6-Tetrahydrophthalimide 以 硝基苯 作为反应溶剂,化学反应 0.5H,以16%的收率获得产物n-羟基马来酰亚胺
    参考文献:Akiyama,Masayasu; Shimizu,Kazuyuki; Aiba,Seiichi,Journal Of The Chemical Society. Perkin Transactions I,1980,P. 2122-2125
    标题:Akiyama,Masayasu; Shimizu,Kazuyuki; Aiba,Seiichi,Journal Of The Chemical Society. Perkin Transactions I,1980,P. 2122-2125

    海关参考信息

    专利信息


    专利号:US-5665877-A
    优先权日:1993-12-07
    标题:Synthesis of bisindolylmaleimides
    发明人:FAUL MARGARET M; JIROUSEK MICHAEL R; WINNEROSKI II LEONARD L
    权利人:LILLY CO ELI
    摘要:The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.

    专利号:US-5541347-A
    优先权日:1993-12-07
    标 题 :Synthesis of bisindolylmaleimides
    发明人:FAUL MARGARET M; JIROUSEK MICHAEL R; WINNEROSKI II LEONARD L
    权利人:LILLY CO ELI
    摘要:The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.

    专利号:US-10730906-B2
    优先权日:2002-08-01
    标题:Multi-step synthesis of templated molecules
    发明人:PEDERSEN HENRIK
    权利人:PEDERSEN HENRIK; NUEVOLUTIONS AS
    摘要:Disclosed is a method for the manufacture of a library of complexes. The complexes comprise templated molecules attached to the template which directed the synthesis thereof. The templated molecules are produced in a step-by-step fashion which provides for a high local concentration of reactive groups involved in the formation of connections between the individual components of the template molecule.

    专利号:US-9121110-B2
    优先权日:2002-12-19
    标 题 :Quasirandom structure and function guided synthesis methods
    发明人:GOULIAEV ALEX HAAHR; HOLTMANN ANETTE; PEDERSEN HENRIK; FRANCH THOMAS
    权利人:GOULIAEV ALEX HAAHR; HOLTMANN ANETTE; PEDERSEN HENRIK; FRANCH THOMAS; NUEVOLUTION AS
    摘要:The present invention is directed to the synthesis of molecules guided by connector polynucleotides (CPNs) capable of hybridizing to complementary connector polynucleotides (CCPNs) harboring at least one functional entity comprising at least one reactive group. At least one of the CCPNs is capable of hybridizing to at least two CPNs. Each CPN will “callâ€? for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of reactive groups results in the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNsâ€? to at least one “acceptor CCPNâ€? with which the transferred functional entities were not associated prior to the transfer.

    专利号:US-7807764-B2
    优先权日:2003-08-27
    标 题:Composition and process for the controlled synthesis of block copolymers
    发明人:WERMTER HENDRIK; SIMON DIRK; PFAENDNER RUDOLF
    权利人:CIBA SC HOLDING AG
    摘要:The present invention relates to a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) at least one hydroxylamine of high molecular weight, preferably a long chain alkyl substituted hydroxylamine. Further aspects of the present invention are a process for polymerizing ethylenically unsaturated monomers, and the use of high molecular weight hydroxylamines for controlled polymerization.

    专利号:US-9885035-B2
    优先权日:2002-10-30
    标 题 :Method for the synthesis of a bifunctional complex
    发明人:FRANCH THOMAS; GOULIAEV ALEX HAAHR
    权利人:NUEVOLUTION AS
    摘要:Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
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    主要参考文献

    [参考文献]: Yusuke Hibi, Et Al. A Strategy For Sequence Control In Vinyl Polymers Via Iterative Controlled Radical Cyclization. Nat Commun. 2016 Mar 21:7:11064.

    合成参考文献


    摘要:Geffken, D.; Köllner, M. A., Science of Synthesis, (2009) 40, 1007.
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