CAS: 43229-67-0; 1-(4-Benzyloxy-3-Nitrobenzene)-2-{benzyl-[2-(4-Methoxyphenyl)-1-Methylethyl]Amino}Ethanol

该化合物是一种复杂的有机化合物,其特点是分子结构复杂,具有多种功能组,包括一个矿,硝基和甲氧组,有助于其化学反应和潜在的生物活动.芳香环的存在表明,它可能表现出重要的欧元相互作用,影响其溶性及各种溶剂的稳定性.这种化合物可能因其潜在的药用特性而对药用化学感兴趣,尽管具体的生物活动需要经验性调查.其合成和特征通常涉及先进的有机化学技术,包括结构精化的光谱方法.与许多有机化合物一样,安全数据和处理预防措施必不可少,特别是由于硝基组的存在,该组在某些条件下可以产生爆炸性.

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物理性质

MSDS等安全信息

上下游产品

[2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amine 2-(3-benzyloxy-4-nitrophenyl)oxiraneformoterol fumarate 1-(4-benzyloxy-3-aminobenzene)-2-{benzyl-[2-(4-methoxyphenyl)-1-methylethyl]amino}ethanol formoterol

合成工艺路线路线简述

    📜1-(4-甲氧苯基)-2-苄胺基丙烷,1-(4-苄氧基-3-硝基)苯基环氧乙烷 以320.5 G的收率获得产物alpha-[[[2-(4-甲氧基苯基)-1-甲基乙基](苯基甲基)氨基]甲基]-3-硝基-4-(苯基甲氧基)苯甲醇
    参考文献:一种福莫特罗,其可药用盐及其中间体的制备 方法
    标题:一种福莫特罗,其可药用盐及其中间体的制备 方法
    摘要:本发明涉及一种福莫特罗,其可药用盐及其中间体的制备方法.本发明的福莫特罗中间体(式ⅴ所示的化合物)的纯化方法包括如下步骤:I)使式ⅴ所示的化合物粗品和富马酸在有机溶剂a中发反应生成盐反应,制得式ⅴ所示化合物的富马酸盐;ii)使步骤i)得到的式ⅴ所示化合物的富马酸盐与碱在有机溶剂b中发生中和反应,制得纯化的式ⅴ所示的化合物;iii)将步骤ii)得到的纯化的式ⅴ所示的化合物在有机溶剂c中结晶,即得福莫特罗中间体

    海关参考信息

    专利信息


    专利号:US-9029421-B2
    优先权日:2008-06-02
    标 题 :Process for the synthesis of arformoterol
    发明人：HALDAVANEKAR VAISHALI VAMAN; PRABHU MANGESH; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO
    权利人:HALDAVANEKAR VAISHALI VAMAN; PRABHU MANGESH; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; CIPLA LTD
    摘要:The present invention provides a process for preparing a compound of formula (VI) or a salt thereof, the process comprising: (i) reacting 4-methoxyphenyl acetone with an amine of formula (VIII) under conditions of reductive amination to produce a compound of formula (II) or a salt thereof, wherein there is no isolation of an imine intermediate formed during the reductive amination; (ii) condensing the compound (II) or the acid addition salt thereof with an α-haloketone of formula (III) to produce the compound of formula (IV); (iii) reducing the compound (IV) to a compound of formula (V); and (iv) reducing the compound (V) to the compound of formula (VI), wherein the reduction is carried out in the presence of either (1) a hydrogen donating compound in the presence of a hydrogen transfer catalyst; or (2) ammonium formate using a hydrogenation catalyst, wherein R 1 and R 2 are independently optionally substituted arylalkyl, and Hal is selected from chloro or bromo.

    专利号:US-2015210629-A1
    优先权日:2008-06-02
    标题 :Process for the Synthesis of Arformoterol

    专利号:KR-20110015449-A
    优先权日:2008-06-02
    标题:Process for the synthesis of arformoterol

    专利号:EP-2285770-B1
    优先权日:2008-06-02
    标 题 :Process for the synthesis of arformoterol

    专利号:EP-2285770-A1
    优先权日:2008-06-02
    标 题 :Process for the synthesis of arformoterol

    专利号:WO-2009147383-A1
    优先权日:2008-06-02
    标 题 :Process for the synthesis of arformoterol

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    合成参考文献


    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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