CAS: 33396-29-1; Erythromycin A Enol Ether
该化合物是一种经化学修正的红细胞素A衍生物,其特点是引入了一种乙醚功能组,这种改变增强了其稳定性,改变了其反应性特征,使其成为合成大型滑动抗生素和其他专门制药化合物的宝贵中间体. 乙醚会提供选择性反应性,使定向应用能够精确地发挥作用. 其明确界定的结构和高纯度确保研究和工业过程的一贯性能. 该化合物在药用化学中特别有用,有助于开发新型红细胞素类,并改进药理特性. 由于其反应性质,建议在受控条件下进行适当处理.
- 英文名称Erythromycin A Enol Ether
- 中文名称红霉素A烯醇醚
- IUPAC名称(1S,2R,3S,4S,5R,8R,9S,10R,11R)-8-ethyl-2-[(2S,3R,4S,6R)-4-(ethyl-methylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-9,10-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,3,5,9,11,13-hexamethyl-7,15-dioxabicyclo[10.2.1]pentadec-12-en-6-one
- 其它别名6,15-Dioxabicyclo[10.2.1]pentadecane,erythromycin deriv.; 8,9-Anhydroerythromycin A 6,9-hemiketal; Erythromycin A enol ether; Erythromycin enol ether; ME 4
- CAS编号33396-29-1
- MFCD编号:MFCD09840536
- EINECS号:641-788-1
- FDA UNII编号:32B40I7V7B
- 分子式:C37H65NO12分子量:715.91
- 产品CID: 1329446
- 产品分类分析化学 → 标准品 → 法医和兽医标准品
物理性质
MSDS等安全信息
上下游产品
CAS号114-07-8 红霉素 | CAS号105882-69-7 伪赤藓霉素A烯醇醚 | CAS号23893-13-2 Anhydroerythrom...合成工艺路线路线简述
📜红霉素置于溶剂黄146体系中,化学反应 1.0H,以68%的收率获得产物红霉素a烯醇醚
参考文献:Synthesis Of Ring-Contracted Derivatives Of Erythromycin
标题:Synthesis Of Ring-Contracted Derivatives Of Erythromycin
摘要:
DOI:10.1021/jo00228A038
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.
专利号:US-4673736-A
优先权日:1983-07-18
标题:Process for the preparation of (8S)-8-fluoroerythromycins
发明人：TOSCANO LUCIANO
权利人:PIERREL SPA
摘要:For the synthesis of (8S)-8-fluoroerythromycins the corresponding 8,9-anhydroerythromycins 6,9-hemiketal are directly fluorinated with perchloryl fluoride.
专利号:CN-115244061-A
优先权日:2020-01-16
标题:Reagents and their use for modular enantio-divergent synthesis of C-P bonds
专利号:EP-4090664-A1
优先权日:2020-01-16
标 题 :Reagents and their use for modular enantiodivergent synthesis of c-p bonds
专利号:US-2024368378-A1
优先权日:2021-08-30
标 题 :Process for improving resin performance
发明人：SIMPSON NEIL JOHN; NEHACHE SABRINA; MENZEL CLAUDIA
权利人:BORCHERS GMBH
摘要:The invention pertains generally to a process and resulting product of following the steps of the process involving adding an Iron- or Manganese- or Vanadium- or Copper- in combination with a multidentate ligand to form a metal-ligand complex with a thiol or polythiol to an alkyd resin, said steps performed in any order or the synthesis performed in-situ.
专利号:CN-114230553-B
优先权日:2020-09-09
标题 :A kind of asymmetric synthesis method of L-nicotine
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Mizumoto A, Otawa M, Kondo Y, Ito Z, Omura S. [Effect of motilin agonist, EM-523 on gastrointestinal motility]. Nihon Geka Gakkai Zasshi. 1991 Sep;92(9):1208-11. Japanese.
合成参考文献
参考文献:10.1021/jm020250l
摘要:Steinmetz WE, Shapiro BL, Roberts JJ. The structure of erythromycin enol ether as a model for its activity as a motilide. J Med Chem. 2002 Oct 24;45(22):4899–902. doi: 10.1021/jm020250l.
参考文献:10.1073/pnas.0805504105
摘要:Komuro I, Sunazuka T, Akagawa KS, Yokota Y, Iwamoto A, Omura S. Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoforms of C/EBPbeta. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12509–14.
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