CAS: 25333-42-0; (3R)-1-Azabicyclo[2.2.2]Octan-3-Ol

上下游产品

CAS号3731-38-2 3-奎宁环酮 | CAS号854934-70-6 (3R)-1-azabicyc... | CAS号1193-65-3 3-奎宁环酮盐酸盐 | CAS号59653-40-6 (3R)-1-Azabicyc... | CAS号65732-89-0 [(3R)-1-azabicy... | CAS号1619-34-7 奎宁环-3-醇 | CAS号1838-39-7 N-乙酸乙酯-4-哌啶甲酸乙酯 | CAS号827-61-2 乙酰克里定 | CAS号174590-62-6 (R)-quinuclidin... | CAS号242478-37-1 索利那新 | CAS号732228-02-3 (1S)-(3S)-1-Aza... | CAS号740780-79-4 (1R)-(3R)-1-Aza... | CAS号22990-19-8 1-苯基-1,2,3,4-四氢异喹啉 | CAS号774517-20-3 (1R)-(3S)-1-Aza... | CAS号320347-97-5 2-Thiopheneacet... | CAS号62869-69-6 1-Azabicyclo[2....

N-乙酸乙酯-4-哌啶甲酸乙酯置于potassium Tert-Butylate,水,Sodium Hydroxide体系中,用 乙醇,水,甲苯 用作溶剂,化学反应 9.83H,反应生成(R)-(-)-3-奎宁醇
参考文献:一种光学活性3-奎宁醇的制备方法
标题:一种光学活性3-奎宁醇的制备方法
摘要:本发明涉及一种中间体的合成方法,属于有机合成领域.具体说是一种操作简便,成本低廉,适用于工业化生产的光学活性3‑奎宁醇的制备方法.以4‑哌啶甲酸为起始原料,通过酯化,亲核取代,Dieckmann缩合,脱羧,成盐,还原,乙酰化,化学拆分等得到中间体光学活性3‑奎宁醇.上述的反应式如下:

专利信息

专利号:US-7741489-B2
优先权日:2007-03-30
标题:Process for the synthesis of solifenacin
发明人：PUIG SERRANO JORDI; CAMPS PELAYO
权利人:MEDICHEM SA
摘要:The present invention provides an improved synthetic strategy for the preparation of solifenacin and pharmaceutically acceptable salts thereof.

专利号:US-2011077405-A1
优先权日:2008-05-23
标题:Process for preparation of enantiomerically pure (s)-1-phenyi-1,2,3,4- tetrahydroisoquinoline
发明人：ZEGROCKA-STENDEL OLIWIA; ZAGRODZKA JOANNA; LASZCZ MARTA
权利人:ZEGROCKA-STENDEL OLIWIA; ZAGRODZKA JOANNA; LASZCZ MARTA
摘要:Process for preparation of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline wherein 1-phenyl-1,2,3,4-tetrahydroisoquinoline is reacted with D-(−)-tartaric acid in a solvent system comprising of methanol and water, preferably at 3.3:1 to 1:1 volume ratio, the crystallization mixture is left for crystallization and (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline is released from obtained crystalline diastereoisomeric salt according to standard procedures. (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the intermediate in enantiomeric synthesis of solifenacin.

专利号:RU-2008112215-A
优先权日:2005-08-31
标 题 :METHODS OF SYNTHESIS AND INTERMEDIATE COMPOUNDS FOR THE SYNTHESIS OF STEREOISOMERIC COMPOUNDS SUITABLE FOR TREATMENT OF GASTROINTESTINAL DISORDERS AND DISORDERS OF THE CENTRAL NERVOUS SYSTEM

专利号:RU-2418798-C2
优先权日:2005-08-31
标 题 :Synthesis methods and intermediate compounds during synthesis of stereoisomeric compounds, suitable for treating gastrointestinal disorders and central nervous system disorders

专利号:US-2009326230-A1
优先权日:2006-07-19
标题 :Process for preparing solifenacin and its salts
发明人：MATHAD VIJAYAVITTHAL THIPPANNACHAR; LILAKAR JAYDEEPKUMAR DAHYABHAI; GILLA GOVERDHAN; KIKKURU SRIRAMIREDDY; CHINTA RAVEENDRA REDDY; DUDIPALA SWAROOPA
权利人:REDDYS LAB LTD DR; REDDYS LAB INC DR
摘要:The present invention relates to solifenacin in solid form and a process for its preparation and to a process for the preparation of (1S)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline, a key intermediate in the synthesis of solifenacin and its salts.

专利号:US-2010029944-A1
优先权日:2006-11-22
标题:Process for the Synthesis of Solifenacin
发明人：PUIG JORDI; SANCHEZ LAURA; MASLLORENS ESTER; AUGER IGNASI; BOSCH JORDI
权利人:CORPORACION MEDICHEM S L
摘要:This invention provides improved methods for making solifenacin and pharmaceutically acceptable salts thereof. The instant methods are unexpectedly advantageous in their simplicity and efficiency.