参考标题:Synthesis Of Imidazo(4,5-E)(1,4)Diazepine And Imidazo(4,5-E)(1,4)Oxazepine Derivatives Using Caffeidine, A Hydrolysis Product Of Caffeine. 作者:Tsutomu Ohsaki,Takeo Kuriki,Taisei Ueda,Jinsaku Sakakibara,Masahisa Asano 摘要:Synthesis Of Imidazo[4, 5-E][1, 4]Diazepines Using Caffeidine (1) Was Studied. Caffeidine Was Condensed With Various α, β-Unsaturated Carboxylic Acid Derivatives To Give N-(α, β-Unsaturated Acyl)Caffeidines (4). Intramolecular Michael Addition Of 4 Having An Electron-Withdrawing Group At The β-Position Of The α, β-Unsaturated Acyl Group Afforded Imidazo[4, 5-E][1, 4]Diazepines (5, 6). Compounds Of The Same Type (14) Were Also Prepared By Treatment Of N-(α-Halogenoacyl)Caffeidines (13) With Etona In Abs. Etoh. On The Other Hand, Heating Of 13 In H2O Gave Imidazo[4, 5-E][1, 4]Oxazepines (15). Compounds 5D, 15B, And 15C Showed Arterial Relaxing Activities.
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摘要:R.M. Hoskinson. Australian J. Chem. 21, 1913 (1968).